Fluorous tagging compounds and methods of increasing the fluorous nature of compounds

A compound having the formula:

• wherein Rf is a fluorous group selected from the group consisting of a perfluorocarbon, a fluorohydrocarbon, a fluorinated ether or a fluorinated amine having a plurality of carbon-fluorine bonds and having a molecular weight less than 2500, n is an integer between 1 and 6, m is 1, 2 or 3, Ra is an alkyl group or a halo-alkyl group and X is a halide, —N3, —CN, RO—, NH2O—, NHRO—, NR2O—, RCO2—, ROCO2—, RNCO2—, RS—, RC(S)O—, RCS2—, RSC(O)S—, RSCS2— RSCO2—, ROC(S)O—, ROCS2—, RSO2—, RSO3—, ROSO2—, ROSO3—, RPO3—, ROPO3—, an N-imidazolyl group, an N-triazolyl group, an N-benzotriazolyl group, a benzotriazolyloxy group, an imidazolyloxy group, an N-imidazolinone group, an N-imidazolone group, an N-imidazolinethione group, an N-succinimidyl group, an N-phthalimidyl group, an N-succinimidyloxy group, an N-phthalimidyloxy group, —ON═C(CN)R, or a 2-pyridyloxy group, wherein R is an alkyl group, a haloalkyl group, an aryl group, a halo-aryl group, an alkyl-aryl group, a cyano-aryl group, or a nitro-aryl group.