Apoptosis-inducing polypeptides
AssigneeAcademia Sinica
InventorsShu-Mei Liang, Jei-Ming Peng, Chi-Ming Liang
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Abstract
An isolated water-soluble VP1 polypeptide of foot-and-mouth disease virus and a nucleic acid encoding the polypeptide. Also disclosed are a pharmaceutical composition containing the polypeptide or nucleic acid and related methods of inducing apoptosis and treating an apoptosis-related disorder.
Claims20
A method for treating cancer in a subject, the method comprising administering to a subject in need thereof an effective amount of a water-soluble VP1 polypeptide of foot-and-mouth disease virus, wherein the VP1 polypeptide contains RGD, binds to integrin, and induces cell death.
A method for inducing apoptosis in a subject having cancer, the method comprising administering to a subject in need thereof an effective amount of a water-soluble VP1 polypeptide of foot-and-mouth disease virus, wherein the VP1 polypeptide contains RGD, binds to integrin, and induces cell death.
Dependencies are inferred from the claim text.