Method for diagnosing non-small lung cancer
AssigneeOncotherapy Science, Inc.
InventorsYusuke Nakamura, Yataro Daigo, Shuichi Nakatsuru
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Abstract
Disclosed are methods for detecting non-small cell lung cancer (NSCLC) using differentially expressed genes KIF11, GHSR1b, NTSR1, and FOXM1. Also disclosed are methods of identifying compounds for treating and preventing NSCLC, based on the interaction between KOC1 and KIF11, or NMU and GHSR1b or NTSR1.
Claims7
A double-stranded molecule comprising a sense strand and an antisense strand, wherein the sense strand comprises a ribonucleotide sequence corresponding to a KIF11 target sequence, and wherein the antisense strand comprises a ribonucleotide sequence which is complementary to said sense strand, wherein said sense strand and said antisense strand hybridize to each other to form said double-stranded molecule, and wherein said double-stranded molecule, when introduced into a cell expressing a KIF11 gene, inhibits expression of said gene, wherein said KIF11 target sequence consists of SEQ ID NO:
- 34.
A composition for treating non-small cell lung cancer (NSCLC), said composition comprising a pharmaceutically effective amount of an siRNA against KIF11, wherein the siRNA comprises a sense strand and an antisense strand, wherein the sense strand comprises a ribonucleotide sequence corresponding to a KIF11 target sequence, and wherein the antisense strand comprises a ribonucleotide sequence which is complementary to said sense strand, wherein said sense strand and said antisense strand hybridize to each other to form said siRNA, and wherein said siRNA, when introduced into a cell expressing a KIF11 gene, inhibits expression of said gene, wherein said KIF11 target sequence consists of SEQ ID NO:34.
Dependencies are inferred from the claim text.