Loading patent…
AssigneeAnthrogenesis Corporation
InventorsMohammad Heidaran, Jia-Lun Wang, Qian Ye, Andrew Zeitlin, Colleen Suzanne Dulaney
Estimating the term…
The present invention relates to a combination of placental stem cells and stem or progenitor cells derived from a second source, wherein the combination shows improved engraftment as compared to placental stem cells or stem cells from a second source, alone. The combination is referred to as a combined stem cell population. The invention also provides in vitro and in vivo methods for identifying and producing combined stem cell populations, and models of engraftment. In accordance with the present invention, the placental stem cells may be combined with, e.g., umbilical cord blood-derived stem or progenitor cells, fetal or neonatal stem cells or progenitor cells, adult stem cells or progenitor cells, hematopoietic stem cells or progenitor cells, stem or progenitor cells derived from bone marrow, etc.
A combined cell population comprising a number of cells in vitro, said number of cells comprising isolated nucleated placental cells that comprise placental stem cells, and comprising stem cells from a second source, wherein said combined cell population, when cultured for a time and under conditions that allow the formation of colony-forming units, produces more colony-forming units than a number of said isolated nucleated placental cells equivalent to the number of cells in the combined cell population or a number of said stem cells from a second source equivalent to the number of cells in the combined cell population, alone, and
A method of transplantation, comprising transplanting to a recipient a combined cell population comprising a number of isolated nucleated placental cells that comprise placental stem cells, and comprising stem cells from a second source, wherein said combined stem cell population, when transplanted, results in enhanced engraftment compared to transplantation of a number of isolated nucleated placental cells equivalent to the number of cells in the combined stem cell population, or stem cells from a second source equivalent to the number of cells in the combined stem cell population, alone, and
A composition comprising a combined cell population in a container, wherein said combined stem cell population comprises a number of isolated nucleated placental cells comprising placental stem cells, and stem cells from a second source, wherein said composition produces detectably higher engraftment in an individual receiving the composition, compared to an individual who receives said number of isolated nucleated placental cells or said number of stem cells from a second source, alone, and
Dependencies are inferred from the claim text.