Binding molecules against SARS-coronavirus and uses thereof
AssigneeCrucell Holland B.V.
InventorsJan H. Ter Meulen, Cornelis A. De Kruif, Edward N. Van Den Brink, Jaap Goudsmit
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Abstract
The present invention provides binding molecules that specifically bind to SARS-CoV, nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The binding molecules are capable of specifically binding to SARS-CoV and can be used in the diagnosis, prophylaxis and/or treatment of a condition resulting from SARS-CoV.
Claims11
An isolated binding molecule able to specifically bind to a Severe Acute Respiratory Syndrome Coronavirus (SARS-Co-V) and having SARS-CoV neutralizing activity,
- wherein the binding molecule comprises a variable heavy chain comprising amino acid sequence SEQ ID NO:37;
- and
- wherein the binding molecule comprises a variable light chain comprising amino acid sequence SEQ ID NO:41.
An isolated binding molecule able to specifically bind to amino acid residues 11-19 of the nucleocapsid (N) protein (SEQ ID NO:
- 468) of Severe Acute Respiratory Syndrome Coronavirus (SARS-Co-V).
Dependencies are inferred from the claim text.