Genetic polymorphisms associated with coronary events and drug response, methods of detection and uses thereof
AssigneeCelera Corporation
InventorsOlga Iakoubova, James Devlin, Charles Rowland, Carmen Tong
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Abstract
The present invention provides compositions and methods based on genetic polymorphisms that are associated with coronary heart disease (particularly myocardial infarction), aneurysm/dissection, and/or response to drug treatment, particularly statin treatment. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.
Claims25
A method of determining whether a human has an increased risk for coronary heart disease (CHD), comprising:
- a) testing nucleic acid from said human for the presence or absence of a polymorphism in gene KIF6 as represented by position 101 of SEQ ID NO:18 or its complement;
- and
- b) correlating the presence of G at position 101 of SEQ ID NO:
- 18 or C at position 101 of its complement with said human having said increased risk for CHD, or the absence of said G or said C with said human having no said increased risk for CHD.
Dependencies are inferred from the claim text.