Phosphonic acid derivatives and the treating agents of diseases related hyperphosphatemia

A compound of the formula;

• wherein:
• A is selected from —(CH2)n— or —CO—,
• B is a heterocycle or fused heterocycle compound containing a sulfur atom,
• C is a benzene ring,
• D is selected from —(CH2)(n+1)—,
• E is an oxygen atom, and
• P is a phosphine atom,
• wherein R1˜R7 may each be the same or different and are selected from a hydrogen atom, a halogen atom, a nitro group, a cyano group, a straight-chain or branched-chain alkyl group of C1-20, a straight-chain or branched-chain haloalkyl group of C1-20, a straight-chain or branched-chain haloalkoxy group of C1-20, an unsubstituted or substituted aryl group, a heterocycle or fused heterocycle containing a nitrogen, oxygen or sulfur atom, —O—(CH2)(n+1)—OH, an —(CH2)n—O-straight-chain or branched-chain alkyl group of C1-20, an —(CH2)n-unsubstituted or substituted aryl group, an —O—(CH2)(n+1)-unsubstituted or substituted aryl group, an —(CH2)n—S(O)o-straight-chain or branched-chain alkyl group of C1-20, an —O—(CH2)(n+1)—S(O)o-straight-chain or branched-chain alkyl group of C1-20, an —(CH2)n—S(O)o-unsubstituted or substituted aryl group, an —O—(CH2)(n+1)—S(O)o-unsubstituted or substituted aryl group, —(CH2)n—COOR11, —O—(CH2)n—COOR11, —(CH2)n—SO3R11, —O—(CH2)n—SO3R11, —(CH2)n—CONR12R13, —O—(CH2)n—CONR12R13, —(CH2)n— SO2NR12R13, —O—(CH2)n—SO2NR12R13, an —(CH2)n—CO-branched-chain alkyl group of C1-20, an —O—(CH2)n—CO-branched-chain alkyl group of C1-20, an —(CH2)n—CO-unsubstituted or substituted aryl group, an —O—(CH2)n—CO-unsubstituted or substituted aryl group, an amino group, a monosubstituted amino group, a disubstituted amino group, a trisubstituted amino group, a tetrasubstituted amino group, an —O—(CH2)(n+1)—O— amino group, an —O—(CH2)(n+1)—O-monosubstituted amino group, an —O—(CH2)(n+1)—O-disubstituted amino group, an —O—(CH2)(n+1)—O— trisubstituted amino group, an —O—(CH2)(n+1)—O-tetrasubstituted amino group, a substituted amino group with a substituent selected from a straight-chain or branched-chain alkyl group of C1-20, a straight-chain or branched-chain alkanoyl group of C1-20, an unsubstituted or substituted arylcarbonyl group, a straight-chain or branched-chain alkylsulfonyl group of C1-20, an unsubstituted or substituted arylsulfonyl group or straight-chain or branched-chain alkoxycarbonyl group of C1-20,
• R8 and R9 may be the same or different and each are selected from a hydroxyl group and a straight-chain or branched-chain alkoxy group of C1-20,
• R1 and R2 and R4 and R5 can join with a neighboring carbon atom to a 5-7 member saturated or unsaturated hydrocarbon ring or a 5-6 membered fused heterocycle compound, R1, R2 and R3 are each not a hydrogen atom if B is a benzene ring, R11 is a hydrogen atom or a straight-chain or branched-chain alkyl group of C1-20, R12 and R13 are each a hydrogen atom or a straight-chain or branched-chain alkyl group of C1-20, n and m are an integer of from 0-10 and o is an integer of from 0-2, and pharmaceutically acceptable salts thereof.