Monoparamunity inducers based on attenuated rabbit myxomaviruses
AssigneeBavarian Nordic A/S
InventorsAnton Mayr, Barbara Mayr
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Abstract
The present invention relates to monoparamunity inducers based on paramunizing viruses or viral components of a myxomavirus strain from rabbits with typically generalizing disease, to a method for the production thereof and to the use thereof as medicaments for the regulatory optimization of the paramunizing activities for the prophylaxis and therapy of various dysfunctions in humans and animals.
Claims28
An isolated, attenuated myxomavirus, wherein the myxomavirus has lost the receptor properties of one or more myxomavirus interferon receptor, one or more myxomavirus tumor necrosis factor receptor, and one or more myxomavirus interleukin receptor.
An isolated, attenuated myxomavirus, wherein the attenuated myxomavirus has lost the receptor properties of the myxomavirus cytokine receptors IFNα-R, IFNγ-R, TNF-R, IL-1-R, IL-2-R, IL-6-R, and IL-12-R.
An isolated, attenuated myxomavirus, wherein the myxomavirus has lost the receptor properties of a myxomavirus interferon receptor, a myxomavirus TNF-R receptor, and a myxomavirus interleukin receptor.
Dependencies are inferred from the claim text.