Myocardium conditioning using myocardial and parasympathetic stimulation
AssigneeCardiac Pacemakers, Inc.
InventorsJoseph M. Pastore, Tamara Colette Baynham, Andrew P. Kramer, Julio C. Spinelli, Jeffrey Ross, Rodney W. Salo
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Abstract
Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy. The conditioning therapy includes neural stimulation to elicit a parasympathetic response and myocardium pacing. Other aspects and embodiments are provided herein.
Claims30
A system, comprising:
- means for providing cardioprotective therapy to treat heart disease through modulation of an Akt-mediated pathway,
- wherein the means for providing cardioprotective therapy to treat heart disease includes both means for providing cardioprotective myocardial pacing therapy to modulate the Akt-mediated pathway, and means for providing cardioprotective neural stimulation therapy to elicit a parasympathetic response to modulate the Akt-mediated pathway,
- wherein the means for providing cardioprotective myocardial pacing therapy includes means for delivering a programmed myocardial pacing sequence to modulate the Akt-mediated pathway, wherein the means for delivering the programmed myocardial pacing sequence includes means for initiating and timing a sequence of myocardial pacing pulses, wherein the programmed myocardial pacing sequence includes alternating pacing periods with a programmed pacing duration and non-pacing periods with a programmed non-pacing duration, wherein each pacing period in the programmed myocardial pacing sequence includes the timed sequence of myocardial pacing pulses delivered to a myocardium for the duration of each of the pacing periods and not delivering myocardial pacing pulses during each of the non-pacing periods.
A method, comprising:
- providing cardioprotective therapy to treat heart disease through modulation of an Akt-mediated pathway,
- wherein providing cardioprotective therapy to treat heart disease includes both providing cardioprotective myocardial pacing therapy to modulate the Akt-mediated pathway, and providing cardioprotective neural stimulation therapy to elicit a parasympathetic response to modulate the Akt-mediate pathway,
- wherein providing cardioprotective myocardial pacing therapy includes delivering a programmed myocardial pacing sequence to modulate the Akt-mediated pathway, wherein delivering the programmed myocardial pacing sequence includes initiating and timing a sequence of myocardial pacing pulses, wherein the programmed myocardial pacing sequence includes alternating pacing periods with a programmed pacing duration and non-pacing periods with a programmed non-pacing duration, wherein each pacing period in the programmed myocardial pacing sequence includes the timed sequence of myocardial pacing pulses delivered to a myocardium for the duration of each of the pacing periods in the programmed myocardial pacing sequence and not delivering myocardial pacing pulses during each of the a non-pacing periods in the programmed myocardial pacing sequence.
Dependencies are inferred from the claim text.