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US 7,687,641 B2Granted
Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
AssigneeSiga Technologies, Inc.
InventorsRobert F Jordan, Thomas R. Bailey, Susan R. Rippin, Dongcheng Dai
Life of this patent
Estimating the term…
Abstract
Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases cased by the orthopoxvirus.
Claims10
A process for producing ST-246
- of the formula comprising the steps of:
- a) heating a mixture of anti-tricyclo[3.2.2.0]non-6-ene-endo-8, endo-9-dicarboxylic acid anhydride, 4-(trifluoromethyl)benzhydrazide, and ethanol at reflux to form a solution;
- b) cooling the solution;
- c) concentrating the solution to form a residue;
- and
- d) recrystallizing the residue from ethyl acetate and hexanes to obtain ST-246.
3 more elements
A process for producing ST-246
- of the formula comprising the steps of:
- heating a mixture of anti-tricyclo[3.2.2.0]non-6-ene-endo-8, endo-9-dicarboxylic acid anhydride, 4-(trifluoromethyl)benzhydrazide, and ethanol at reflux for 18 hours under a nitrogen atmosphere to form a solution;
- cooling the solution to room temperature;
- concentrating the solution in vacuo to form a residue;
- and
- recrystallizing the third residue from ethyl acetate and hexanes to obtain ST-246.
3 more elements
Dependencies are inferred from the claim text.