Biosensor membrane material
AssigneeiSense Corporation
InventorsRobert S. Ward, Yuan Tian, W. Kenneth Ward, Ellen Anderson, Jody House
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Abstract
Embodiments of the present invention provide various multipolymers and permselective membranes for use with biosensors and other implantable medical devices and prostheses. Embodiments of the present invention may provide structural strength and integrity, and further may control the influx of glucose, oxygen and/or water. Embodiments of the present invention may, for example, minimize or reduce the influx of glucose by minimizing the percentage of hydrophilic segments, which in turn minimizes the percentage of water uptake and the degree of glucose transport.
Claims4
A biocompatible multipolymer capable of forming a glucose-limiting permselective membrane, said multipolymer having
- a hydrophilic soft segment, wherein less than about 5% of total soft segment weight is made up of the hydrophilic soft segment;
- and
- an oxygen-permeable soft segment, wherein said oxygen-permeable soft segment comprises at least one of a perfluorinated or partially fluorinated hydrocarbon and a perfluorinated or partially fluorinated polyalkylsiloxane.
A biocompatible multipolymer capable of forming a glucose-limiting permselective membrane, said multipolymer having
- a hydrophilic soft segment, wherein less than about 5% of total soft segment weight is made up of the hydrophilic soft segment;
- and
- surface modifying end groups, wherein said surface modifying end groups comprise at least one of perfluorinated or partially fluorinated hydrocarbons, perfluorinated or partially fluorinated polyethers, and perfluorinated or partially fluorinated polyalkylsiloxanes.
A glucose-limiting permselective membrane, comprising:
- a multipolymer having at least one soft segment, wherein less than about 5% of total soft segment weight is made up of a hydrophilic soft segment and wherein said membrane has an average loss of sensitivity to analyte permeation of less than 10% over an oxygen tension range between 30 Torr and 150 Torr.
A glucose-limiting permselective membrane, comprising:
- a multipolymer having at least one soft segment, wherein less than about 5% of total soft segment weight is made up of a hydrophilic soft segment and wherein said membrane has an average loss of sensitivity to analyte permeation of less than 5% over an oxygen tension range between 30 Torr and 150 Torr.
Dependencies are inferred from the claim text.