Pharmaceutical compositions of hydrophobic compounds
AssigneeFormatech, Inc.
InventorsJohn G. Augustine, Kaliappanadar Nellaiappan, Benjamin S. Isaacs, Indu J. Isaacs
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Abstract
This invention concerns novel methods of enhancing the solubility of a compound. Compositions prepared using such methods are also disclosed. Compositions prepared using the methods have various advantages over conventionally known compositions.
Claims10
A micellar pharmaceutical composition in a form of a solution comprising a hydrophobic compound, wherein:
- (1) the hydrophobic compound is solubilized using a fatty acid salt or a fatty alcohol, and at a greater concentration than the solubility of the compound in water;
- (2) said pharmaceutical composition contains no ethanol;
- (3) said pharmaceutical composition is made using no oil;
- and (4) said pharmaceutical composition is stable.
A pharmaceutical composition which (1) is lyophilized from a micellar composition in a form of a solution comprising paclitaxel, cyclosporin A, acetylsalicylic acid or digoxin, or a pharmaceutically acceptable salt, solvate, hydrate, clathrate or prodrug thereof, solubilized using a fatty acid salt or a fatty alcohol and using no oil;
- (2) contains no bulking agent or detergent;
- (3) can be reconstituted in an aqueous solution within 30 minutes;
- and (4) greater than 90 percent of the paclitaxel, cyclosporin A, acetylsalicylic acid or digoxin, or a pharmaceutically acceptable salt, solvate, hydrate, clathrate or prodrug thereof, remains in solution at room temperature at least one hour after reconstitution.
Dependencies are inferred from the claim text.