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US 7,683,193 B2Granted
Benzo lipoxin analogues
AssigneeUniversity of Southern California
InventorNicos A. Petasis
Life of this patent
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Abstract
Benzolipoxin analogs, methods of their preparation and pharmaceutical compositions containing the compounds are provided. The compounds and compositions are useful in methods for treatment of various diseases, including, inflammation, autoimmune disease and abnormal cell proliferation.
Claims16
A compound represented by one of the following structural formulae:
- wherein:
- A is hydroxy, alkoxy, aryloxy, amino, alkylamino, dialkylamino or —OM, wherein M is an ammonium, tetra-alkyl ammonium, sodium, potassium, magnesium or zinc cation;
- W is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, halo, hydroxy, alkoxy, aryloxy, carboxy, amino, alkylamino, dialkylamino, acylamino, carboxamido, or sulfonamide;
- Ra-Rc are each independently hydrogen, alkyl, aryl, acyl or alkoxyacyl;
- n is zero, one or two;
- and
- m is one or two,
- or a pharmaceutically acceptable salt thereof.
5 more elements
Dependencies are inferred from the claim text.