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US 7,683,187 B2Granted
Process for producing delta-lactones
AssigneeDanisco A/S
InventorsLars Wiebe, Thomas Schmidt
Life of this patent
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Abstract
The present invention relates to a process for preparing a lactone. The process comprises the steps of reacting an aldehyde with an organic halide in a carbon chain extension reaction to form an alcohol compound comprising a functional group capable of allowing for carbonylation of said alcohol compound, and then reacting said alcohol compound in a carbonylation reaction to form an hydroxycarboxylic acid; and cyclizing the hydroxycarboxylic acid to produce the lactone.
Claims17
A process for preparing a delta-lactone comprising the steps of
- a) reacting an aldehyde with an unsaturated organic halide in a carbon chain extension reaction, wherein the carbon chain extension reaction is carried out in the presence of water, using a catalyst comprising a mixture of aluminum, copper, tin(II) chloride and sodium iodide or a catalyst comprising a mixture of copper and tin(II) chloride, to form an alcohol compound comprising a functional group capable of allowing for carbonylation of said alcohol compound;
- b) reacting said alcohol compound with a source of carbon monoxide in a carbonylation reaction in the presence of water, using a catalytic system comprising a transition metal and/or a salt of a transition metal wherein the transition metal is selected from cobalt, iridium, palladium, platinum, rhodium, and mixtures thereof, wherein the catalytic system further comprises a tin(II) chloride co-catalyst and a ligand comprising at least one donor atom selected from nitrogen, phosphorous, arsenic, antimony and bismuth to form an hydroxycarboxylic acid;
- and
- c) cyclising the hydroxycarboxylic acid to produce the delta-lactone.
1 more element
Dependencies are inferred from the claim text.