Cyclic N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, pharmaceutical compositions and methods for the therapeutic use thereof

A compound of formula I:

• wherein
• R1 is selected from the group consisting of (C1-C6)alkyl, (C0-C6)alkylene (C3-C6)cycloalkyl, (C0-C6)alkylene-O—(C1-C6)alkyl, (C0-C6)alkylene-O—(C3-C6)cycloalkyl, (C0-C6)alkylene-(C6-C14)aryl and (C0-C6)alkylene-(C5-C15)heteroaryl, wherein alkyl, alkylene, aryl, heteroaryl and cycloalkyl can be un-substituted or mono-, di- or tri-substituted selected from the group consisting of F, Cl, Br, (C1-C6)alkyl, O—(C1-C6)alkyl, CF3, OCF3, CN, CO—(C1-C6)alkyl, COO(C1-C6)alkyl, CON((C0-C6)alkylene-H)((C0-C6)alkylene-H), and S(O)m(C1-C6)alkyl;
• R2 and R3 are independently selected from the group consisting of H, halogen, (C1-C6)alkyl, (C0-C4)alkylene-O—(C0-C4)alkylene-H, CN, COO(C1-C6)alkyl, CON((C0-C6)alkylene-H)((C0-C6)alkylene-H) and S(O)m(C1-C6)alkyl, wherein alkyl and alkylene are un-substituted or mono, di- or trisubstituted by F;
• A is (C6-C14)aryl or (C3-C12)heteroaryl;
• R4 and R5 are independently selected from the group consisting of H, (C1-C6)alkyl, CN, CO—(C1-C6)alkyl, COO—(C1-C6)alkyl, CON((C0-C6)alkylene-H((C0-C6)alkylene-H), S(O)m(C1-C6)alkyl, N((C0-C6)alkylene-H)((C0-C6)alkylene-H), N((C0-C6)alkylene-H)—CO—(C1-C6)alkyl, N((C0-C6)alkylene-H)—CO—(C1-C6)alkyl, halogen, (C0-C6)alkylene-O—(C0-C6)alkylene-H, (C0-C6)alkylene-O—(C6-C14)aryl, SCF3, S(O)2CF3 and NO2, wherein alkyl and alkylene are un-substituted or mono-, di- or tri-substituted by F;
• R6, R7, R8 and R9 are independently selected from the group consisting of H, (C1-C6)alkyl, (C0-C6)alkylene-(C3-C6)cycloalkyl, (C0-C6)alkylene-(C6-C14)aryl, (C0-C6)alkylene-(C5-C15)heteroaryl, (C0-C6)alkylene-(C3-C15)heterocycloalkyl, and (C0-C6)alkylene-(C3-C15)heterocycloalkenyl, wherein alkyl, alkylene and cycloalkyl are un-substituted or mono-, di- or tri-substituted selected from the group consisting of halogen, (C1-C6)alkyl, (C0-C6)alkylene-O—(C0-C6)-alkylene-H, CF3, OCF3, CN, CO—(C1-C6)alkyl, COO—(C1-C6)alkyl, CON((C0-C6)alkylene-H)((C0-C6)alkylene-H) and S(O)m(C1-C6)alkyl wherein aryl, cycloalkyl, heterocycloalkyl, heterocycloalkenyl and heteroaryl are un-substituted or mono-, di- or tri-substituted selected from the group consisting of halogen, CF3, (C1-C6) alkyl and (C0-C4)alkylene-O—(C0-C4)alkylene-H, and
• wherein at least one pair of the substituents R6 and R7, R8 and R9, or R7 and R8 together with the carbon atoms to which they are connected form a (C3-C13)cycloalkyl, a (C3-C9)-heterocycloalkyl or a (C3-C9)-heterocycloalkenyl, wherein cycloalkyl, heterocycloalkyl and heterocycloalkenyl are un-substituted or mono-, di- or tri-substituted selected from the group consisting of halogen, CF3, (C1-C6)alkyl and (C0-C4)alkylene-O—(C0-C4)alkylene-H;
• m is 0, 1 or 2;
• its' stereoisomers, enantiomers, tautomers, their salts and mixtures thereof.