US 7,683,176 B2 · Triazolyl pyridyl benzenesulfonamides

A compound of the formula (I), or a salt thereof:

wherein
Ar is selected from the group consisting of substituted or unsubstituted C6-10 aryl;
Y1 is —CR3a;
Y2 is —CR3b;
Y3 is —CR3b;
Y4 is —N;
R3a, R3b, and R3c are each independently selected from the group consisting of hydrogen, halogen, —CN, —C(O)R4, —CO2R4, —C(O)NR4R5, —OR4, —OC(O)R4, —OC(O)NR4R5, —SR4, —S(O)R4, —S(O)2R4, —S(O)2NR4R5, —NO2, —NR4R5, —NR4C(O)R5, —NR4C(O)OR5, —NR4S(O)2R5, —NR4C(O)NR5R6, substituted or unsubstituted C1-8 alkyl, substituted or unsubstituted C2-8 alkenyl, substituted or unsubstituted C2-8 alkynyl, and substituted or unsubstituted C6-10 aryl;
R4, R5, and R6 are each independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-8 alkyl, substituted or unsubstituted C2-8 alkenyl, substituted or unsubstituted C2-8 alkynyl, and substituted or unsubstituted C6-10 aryl;
R1 is an unsubstituted isoxazolyl or an isoxazolyl substituted with 1 or 2 substituents independently selected from the group consisting of halogen, —CN, —CO2R′, —C(O)R′, —C(O)NR′R″, —OR′, —OC(O)R′, —OC(O)NR′R″, —NO2, —NR′C(O)R″, —NR″′C(O)NR′R″, —NR′R″, —NR′CO2R″, —NR′S(O)R″, —NR′S(O)2R″′, —NR″′S(O)NR′R″, —NR″′S(O)2NR′R″, —SR′, —S(O)R′, —S(O)2R′, —S(O)2NR′R″, —NR′—C(NHR″)═NR″′, —SiR′R″R″′, —N3, and unsubstituted C6-10 aryl;
R2 is selected from the group consisting of hydrogen, halogen, —CN, —C(O)R7, —CO2R7, —C(O)NR7R8, —OR7, —OC(O)R7, —OC(O)NR7R8, —SR7, —S(O)R7, —S(O)2R7, —S(O)2NR7R8, —NO2, —NR7R8, —NR7C(O)R8, —NR7C(O)OR8, —NR7S(O)2R8, —NR7C(O)NR8R9, substituted or unsubstituted C1-8 alkyl, substituted or unsubstituted C2-8 alkenyl, substituted or unsubstituted C2-8 alkynyl, and substituted or unsubstituted C6-10 aryl;
and
R7, R8, and R9 are each independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-8 alkyl, substituted or unsubstituted C2-8alkenyl, substituted or unsubstituted C2-8alkynyl, and substituted or unsubstituted C6-10 aryl;
wherein said substituted C1-8 alkyl, substituted C2-8 alkenyl, and substituted C2-8 alkynyl have 1 to (2m′=1) substituents, where the substituents are independently selected from the group consisting of halogen, —CN, —CO2R′, —C(O)R′, —C(O)NR′R″, —OR′, —OC(O)R′, —OC(O)NR′R″, —NO2, —NR′C(O)R″, —NR″′C(O)NR′R″, —NR′R″, —NR′CO2R″, —NR′S(O)R″, —NR′S(O)2R″′, —NR″′S(O)NR′R″, —NR″′S(O)2NR′R″, —SR′, —S(O)R′, —S(O)2R′, —S(O)2NR′R″, —NR′—C(NHR″)═NR″′, —SiR′R″R″′, —N3, and unsubstituted C6-10 aryl;
wherein m′ is the total number of carbons in said substituted alkyl, substituted alkenyl, and substituted alkynyl;
wherein said substituted C6-10 aryl have 1 to 5 substituents independently selected from the group consisting of halogen, —CN, —CO2R′, —C(O)R′, —C(O)NR′R″, oxo(=O or —O−), —OR′, —OC(O)R′, —OC(O)NR′R″, —NO2, —NR′C(O)R″, —NR″′C(O)NR′R″, —NR′R″, —NR′CO2R″, —NR′S(O)R″, —NR′S(O)2R″′, —NR″′S(O)NR′R″, —NR″′S(O)2NR′R″, —SR′, —S(O)R′, —S(O)2R′, —S(O)2NR′R″, —NR′—C(NHR″)═NR″′, —SiR′R″R″′, —N3, and unsubstituted C6-10 aryl;
and
wherein R′, R″and R″′ are each independently selected from the group consisting of:
hydrogen, unsubstituted C1-8 alkyl, unsubstituted C2-8 alkenyl, unsubstituted C2-8 alkynyl, and unsubstituted C6-10 aryl.

15 more elements

A compound which is represented by formula (II) or a salt thereof:

wherein
Ar is selected from the group consisting of substituted or unsubstituted C6-10 aryl;
Y5, Y6 and Y7 are each independently selected from the group consisting of hydrogen, halogen, —CN, —C(O)R15, —CO2R15, —C(O)NR15R16, —OR15, —OC(O)R15, —OC(O)NR15R16, —SR15, —S(O)R15, —S(O)2R15, —S(O)2NR15R16, —NO2, —NR15R16, —NR15C(O)R16, —NR15C(O)OR16, —NR15S(O)2R16, —NR15C(O)NR16R17, substituted or unsubstituted C1-8 alkyl, substituted or unsubstituted C2-8 alkenyl, substituted or unsubstituted C2-8 alkynyl, and substituted or unsubstituted C6-10 aryl;
and
R15, R16 and R17 are each independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-8 alkyl, substituted or unsubstituted C2-8 alkenyl, substituted or unsubstituted C2-8 alkynyl, and substituted or unsubstituted C6-10 aryl R1 is an unsubstituted isoxazolyl or an isoxazolyl substituted with 1 or 2 substituents independently selected from the group consisting of halogen, —CN, —CO2R′, —C(O)R′, —C(O)NR′R″, —OR′, —OC(O)R′, —OC(O)NR′R″, —NO2, —NR′C(O)R″, —NR″′C(O)NR′R″, —NR′R″, —NR′CO2R″, —NR′S(O)R″, —NR′S(O)2R″′, —NR″′S(O)NR′R″, —NR″′S(O)2NR′R″, —SR′, —S(O)R′, —S(O)2R′, —S(O)2NR′R″, —NR′—C(NHR″)═NR″′, —SiR′R″R″′, —N3, and unsubstituted C6-10 aryl;
R2 is selected from the group consisting of hydrogen, halogen, —CN, —C(O)R7, —CO2R7, —C(O)NR7R8, —OR7, —OC(O)R7, —OC(O)NR7R8, —SR7, —S(O)R7, —S(O)2R7, —S(O)2NR7R8, —NO2, —NR7R8, —NR7C(O)R8, —NR7C(O)OR8, —NR7S(O)2R8, —NR7C(O)NR8R9, substituted or unsubstituted C1-8 alkyl, substituted or unsubstituted C2-8 alkenyl, substituted or unsubstituted C2-8 alkynyl, and substituted or unsubstituted C6-10 aryl;
wherein said substituted C1-8 alkyl, substituted C2-8 alkenyl, and substituted C2-8 alkynyl have 1 to (2m′=1) substituents, where the substituents are independently selected from the group consisting of halogen, —CN, —CO2R′, —C(O)R′, —C(O)NR′R″, —OR′, —OC(O)R′, —OC(O)NR′R″, —NO2, —NR′C(O)R″, —NR″′C(O)NR′R″, —NR′R″, —NR′CO2R″, —NR′S(O)R″, —NR′S(O)2R″′, —NR″′S(O)NR′R″, —NR″′S(O)2NR′R″, —SR′, —S(O)R′, —S(O)2R′, —S(O)2NR′R″, —NR′—C(NHR″)═NR″′, —SiR′R″R″′, —N3, and unsubstituted C6-10 aryl;
wherein m′ is the total number of carbons in said substituted alkyl, substituted alkenyl, and substituted alkynyl;
wherein said substituted C6-10 aryl have 1 to 5 substituents independently selected from the group consisting of halogen, —CN, —CO2R′, —C(O)R′, —C(O)NR′R″, oxo(=O or —O−), —OR′, —OC(O)R′, —OC(O)NR′R″, —NO2, —NR′C(O)R″, —NR″′C(O)NR′R″, —NR′R″, —NR′CO2R″, —NR′S(O)R″, —NR′S(O)2R″′, —NR″′S(O)NR′R″, —NR″′S(O)2NR′R″, —SR′, —S(O)R′, —S(O)2R′, —S(O)2NR′R″, —NR′—C(NHR″)═NR″′, —SiR′R″R″′, —N3, and unsubstituted C6-10 aryl;
and
wherein R′, R″ and R″′ are each independently selected from the group consisting of:
hydrogen, unsubstituted C1-8 alkyl, unsubstituted C2-8 alkenyl, unsubstituted C2-8alkynyl, and unsubstituted C6-10 aryl.

9 more elements

Triazolyl pyridyl benzenesulfonamides

Life of this patent

Triazolyl pyridyl benzenesulfonamides

Life of this patent

Abstract

Claims18