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US 7,683,175 B2Granted
Process of making optically pure L-pipecolic acid and process of making anesthetics and intermediates therefrom
AssigneeNavinta LLC
InventorsJagadeesh B. Rangisetty, Manik R. Pullagurla, Raja J. J. Muthiah, Christopher N. Jobdevairakkam
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Abstract
The present invention describes a novel process of preparation of optically pure L-Pipecolic acid and an improved process for the conversion of L-pipecolic acid to L-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinocarboxamide, its hydrochloride salt and hydrochloride monohydrate.
Claims3
A process for the preparation of pure L-N-pipecolylxylidide, comprising:
- (a) preparing L-pipecolic acid chloride hydrochloride from pure L-pipecolic acid hydrochloride phosphorous pentachloride at a temperature range of about −30° C. to 20° C.;
- and
- (b) reacting the L-pipecolic acid chloride hydrochloride obtained in step (a) with xylidine at a temperature range of about −30° C. to 20° C. to produce optically pure L-N-pipecolylxylidide.
Dependencies are inferred from the claim text.