Urea derivative and process for preparing the same
AssigneeEisai R&D Management Co., Ltd.
InventorsToshihiko Naito, Kazuhiro Yoshizawa
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Abstract
A process for preparing a compound (C) represented by the following formula: wherein R1 represents hydrogen, C1-6 alkyl or C3-8 cycloalkyl, and R2 represents hydrogen or methoxy, characterized by reacting a compound (A-1) represented by the following formula: wherein R1 has the same definition as above, with a compound (B) represented by the following formula: wherein R2 has the same definition as above, and L represents a leaving group, is provided. Compound (C) is effective for prevention or treatment of various diseases associated with angiogenesis neoplasia.
Claims9
A process for preparing a compound (C) or a salt thereof represented by the following formula:
- wherein R1 represents hydrogen, C1-6 alkyl or C3-8 cycloalkyl, and wherein R2 represents hydrogen or methoxy, said method comprising reacting a compound (A-1) represented by the following formula:
- wherein R1 has the same definition as above, with a compound (B) represented by the following formula:
- wherein R2 is defined as above, and L represents a leaving group.
Dependencies are inferred from the claim text.