Compositions of novel opioid compounds and method of use thereof
AssigneeMount Cook Bio Sciences, Inc.
InventorsShyi-Tai Jan, Kwen-Jen Chang, Kestutis P. Biciunas, Xin Ma
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Abstract
Diarylmethylpiperazine compounds are described, which are useful as mu and/or delta receptor opioid compounds, without central side effects. Pharmaceutical compositions containing such compounds are variously useful for peripheral or non-centrally mediated indications, including peripherally mediated and neuropathic pain, urogenital tract disorders, overactive bladder, urinary incontinence, sexual disorders, premature ejaculation, cough, lung edema, cardiac disorders, cardioprotection, gastro-intestinal disorders, diarrhea, irritable bowl syndrome, functional distention, immuno-modulation and anti-tumor activity.
Claims1
A compound of the formula
- wherein:
- Z is H, O(CH2)nCH3, wherein n=0 to 4, or OH;
- X is —C═O which is on the meta or para position of the phenyl ring;
- DL is a group having a nitrogen that is covalently bonded to the carbon atom of group X;
- R1 is C1-C6 alkyl, C1-C6 alkenyl, C1-C6 cycloalkylmethyl, arylalkyl having C5-C10 aryl and C1-C6 alkyl moieties, halobenzyl or carboxybenzyl;
- and
- wherein the DL is selected from the group consisting of:
Dependencies are inferred from the claim text.