Nucleic acid derivatives
AssigneeBio-Rad Laboratories, Inc.
InventorDavid Segev
Life of this patent
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Abstract
A compound which comprises a backbone having a plurality of chiral carbon atoms, the backbone bearing a plurality of ligands each being individually bound to a chiral carbon atom of the plurality of chiral carbon atoms, the ligands including one or more pair(s) of adjacent ligands each containing a moiety selected from the group consisting of a naturally occurring nucleobase and a nucleobase binding group, wherein moieties of the one or more pair(s) are directly linked to one another via a linker chain; building blocks for synthesizing the compound; and uses of the compound, particularly in antisense therapy.
Claims19
A compound having a formula:
- wherein:
- L is a linker chain;
- each of B1 and B2 is a chemical functionality group selected from the group consisting of a protected or unprotected naturally occurring nucleobase and a protected or unprotected nucleobase binding group;
- each of Y1 and Y2 is a first linker group;
- each of X1 and X2 is a second linker group;
- C1 and C2 are chiral carbon atoms;
- Z is a first protecting group;
- and
- A is a leaving group.
Dependencies are inferred from the claim text.