Colchicoside analogues
AssigneeIndena S.p.A.
InventorsEzio Bombardelli, Gabriele Fontana
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Abstract
The present invention relates to colchicine derivatives, in particular to the 3-demethyl and 3-demethylthio-colchicine of the general formula (I) in which X is oxygen or sulfur, a method for the preparation thereof and pharmaceutical compositions containing them. The compounds of formula (I) have muscle relaxing, anti-inflammatory and anti-gout activity.
Claims15
A compound of the general formula (I):
- in which X is oxygen or sulfur.
A compound selected from the group consisting of 3-O-β-D-xylopyranosyl-3-O-demethylthiocolchicine and 3-O-β-L-xylopyranosyl-3-O-demethylthiocolchicine.
A medicament comprising a compound of the general formula (I):
- in which X is oxygen or sulfur.
A pharmaceutical composition containing a compound of the general formula (I):
- in which X is oxygen or sulfur, the compound being in admixture with suitable excipients and/or carriers.
Dependencies are inferred from the claim text.