Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture

A glucopyranosyl-substituted benzyl-benzene derivative of general formula I

• wherein
• R1 denotes hydrogen, fluorine, chlorine, bromine, iodine, C1-4-alkyl, C2-6-alkynyl, C1-4-alkoxy, C2-4-alkenyl-C1-4-alkoxy, C2-4-alkynyl-C1-4-alkoxy, methyl substituted by 1 to 3 fluorine atoms, ethyl substituted by 1 to 5 fluorine atoms, methoxy substituted by 1 to 3 fluorine atoms, ethoxy substituted by 1 to 5 fluorine atoms, C1-4-alkyl substituted by a hydroxy or C1-3-alkoxy group, C2-4-alkoxy substituted by a hydroxy or C1-3-alkoxy group, C2-6-alkenyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-3-alkyl, C3-7-cycloalkyloxy, C3-7-cycloalkyl-C1-3-alkoxy, C5-7-cycloalkenyloxy, hydroxy, amino, nitro or cyano, while in the C5-6-cycloalkyl groups a methylene group may be replaced by O;
• R2 denotes hydrogen, fluorine, chlorine, bromine, hydroxy, C1-4-alkyl, C1-4-alkoxy, cyano or nitro, while the alkyl or alkoxy group may be mono- or polysubstituted by fluorine, and
• R3 denotes C3-7-cycloalkyl, tetrahydrofuranyl or tetrahydropyranyl, which are substituted with one to four substituents L2, or R3 denotes C5-7-cycloalkanonyl which may be substituted with one to four substituents L2;
• and
• R4, R5 independently of one another denote hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, C1-3-alkyl, C1-3-alkoxy or a methyl- or methoxy-group substituted by 1 to 3 fluorine atoms,
• L1 independently of one another are selected from among fluorine, chlorine, bromine, iodine, hydroxy, cyano, C1-3-alkyl, difluoromethyl, trifluoromethyl, C1-3-alkoxy, difluoromethoxy, trifluoromethoxy, amino, C1-3-alkyl-amino and di(C1-3-alkyl)-amino;
• and
• L2 independently of one another are selected from among fluorine, chlorine, hydroxy, hydroxyl-C1-4-alkyl, C1-4-alkoxy, trifluoromethoxy, C1-4-alkoxy-C1-4-alkyl, cyano, hydroxycarbonyl, (C1-4-alkyl)oxycarbonyl, aminocarbonyl, C1-4-alkyl, trifluoromethyl, amino, C1-4-alkyl-carbonylamino, C1-3-alkyl-amino and di(C1-3-alkyl)-amino;
• and
• R6, R7a, R7b, R7c independently of one another have a meaning selected from among hydrogen, (C1-18-alkyl)carbonyl, (C1-18-alkyl)oxycarbonyl, arylcarbonyl and aryl-(C1-3-alkyl)-carbonyl, while the aryl-groups may be mono- or disubstituted independently of one another by identical or different groups L1;
• while by the aryl groups mentioned in the definition of the above groups are meant phenyl or naphthyl groups which may be substituted as defined;
• and
• while, unless otherwise stated, the above-mentioned alkyl groups may be straight-chain or branched,
• the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof.