Topoisomerase inhibitors

A compound of formula

• or a pharmaceutically acceptable salt thereof,
• wherein R1 is a member selected from the group consisting of hydrogen, (C1-C8)alkyl, (C1-C8)heteroalkyl, (C3-C8)heterocycloalkyl(C1-C8)alkyl and aryl(C1-C8)alkyl;
• R2 has the formula:
• wherein
• X7 is N, O, or S and when X7 is S or O, either R21 or R24 is absent;
• g is an integer from 1-6;
• R21, R22, R23 and R24 are each independently a member selected from the group consisting of hydrogen, halogen, halo(C1-C6)alkyl, (C1-C6)alkyl, (C3-C6)cycloalkyl, aryl, heteroaryl, aryl(C1-C6)alkyl and —C(O)2R25;
• wherein R25 is hydrogen;
• alternatively, when X7 is N then R21 and R24 taken together with X7 join to form a 4-to 7-membered ring containing 0-3 heteroatoms, wherein said 4-to 7-membered ring is optionally substituted with 1-3 substituents selected from the group consisting of (C1-C6)alkyl, (C1-C6)acyl, aryl, heteroaryl, hydroxy, alkoxy, amino and alkylamino;
• alternatively, R23 and R24 taken together with the atoms to which they are attached join to form a 4- to 7-membered ring containing 0-3 heteroatoms, wherein said 4- to 7-membered ring is optionally substituted with 1-3 substitutents selected from the group consisting of (C1-C6)alkyl, (C1-C6)heteroalkyl, hydroxy and C(O)2R26, wherein R26 is hydrogen or (C1-C4)alkyl;
• Z is a bond;
• and
• R3 is a member selected from the group consisting of hydrogen, halogen, alkyl, alkoxy, hydroxy, halo(C1-C6)alkyl, heteroalkyl, —NO2, —CN, —CH2CN, —SR9, —O—S(O)R9, —S(O)2R9, and —S(O)R9, wherein R9 is a member selected from the group consisting of (C1-C4)alkyl, amino and alkylamino.

A compound selected from group consisting of:

• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (2-methoxy-pyrimidin-5-yl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid pyrazin-2-ylamide,
• 6-Chloro-3″-carboxamido-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-methoxy-pyridin-3-yl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-methoxy-pyridin-3-yl)-amide,
• 6-Chloro-3″-hydroxy-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-methoxy-pyridin -3-yl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-chloro-pyridin-3-yl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-fluoro-pyridin-3-yl)-amide,
• 6-Chloro-[1,1′;4′, 1″]terphenyl-3-carboxylic acid (6-methyl-pyridin-3-yl)-amide,
• 6-Chloro-3″-hydroxymethyl-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-methoxy-pyridin-3-yl)-amide,
• 6-Chloro-4″-hydroxy-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-methoxy-pyridin-3-yl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid p-tolylamide,
• 6-Chloro-4″-hydroxymethyl-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-methoxy-pyridin-3-yl)-amide,
• 6-Chloro-3″-methanesulfonyl-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-methoxy-pyridin-3-yl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid [1,2,4]triazin-3-ylamide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide,
• 5-Fluoro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-methoxy-pyridin-3-yl)-amide,
• 6-Methyl-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-methoxy-pyridin-3-yl)-amide,
• 6″-Chloro-2′-fluoro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid pyridin-3-ylamide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (2-pyridin-3-yl-2-pyrrolidin-1-yl -ethyl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (4,5-dihydro-thiazol-2-yl)-amide,
• 6″-Chloro-4-dimethylaminomethyl-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (6-methoxy-pyridin-3-yl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (2-diethylamino-ethyl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (6-piperazin-1-yl-pyridin-3-yl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid pyrimidin-4-ylamide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid 3-aminomethyl-benzylamide,
• 4-Methyl-piperazine-1-carboxylic acid 2-chloro-5-(6-methoxy-pyridin-3-ylcarbamoyl)-[1,1′;4′,1″]terphenyl-4″-yl ester,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (piperidin-4-ylmethyl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-hydroxymethyl-pyridin-3-yl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid piperidin-4-ylamide,
• 6-Chloro-[1,1 ′;4′,1″]terphenyl-3-carboxylic acid (6-methylsulfanyl-pyridin-3-yl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid [6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-amide,
• 6-Methyl-[1,1′;4′,1″]terphenyl-3-carboxylic acid (5-chloro-pyridin-2-yl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (5-phenyl-[1,3,4]oxadiazol-2-yl)-amide,
• 6-Chloro-3″-dimethylaminomethyl-[1,1′;4′,1″]terphenyl-3-carboxylic acid (4-methoxy-phenyl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (2-dimethylamino-ethyl)-pyridin-3-yl-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (6-methanesulfonyl-benzothiazol-2-yl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (tetrahydro-furan-2-ylmethyl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-yl)-(3-dimethylamino-pyrrolidin-1-y-1)-methanone,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid [3-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-amide,
• 4″-Benzyloxy-6-chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-methoxy-pyridin-3-yl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid pyridin-3-ylamide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (furan-2-ylmethyl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid quinolin-6-ylamide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (3-fluoro-4-methoxy-phenyl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid [6-(2-dimethylamino-ethylsulfanyl)-pyridin-3-yl]-amide,
• 2-Chloro-5-(6-methoxy-pyridin-3-ylcarbamoyl)-[1,1′;4′,1″]terphenyl-3″-carboxylic acid,
• 4″-Aminomethyl-6-chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-methoxy-pyridin-3-yl)-amide,
• 6-Chloro-3″-formyl-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-methoxy-pyridin-3-yl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid methyl-(2-pyridin-2-yl-ethyl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (2-methylsulfanyl-pyrimidin-5-yl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (5-chloro-pyrimidin-2-yl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (4-ethoxy-phenyl)-amide,
• (3-Amino-pyrrolidin-1-yl)-(6-chloro-[1,1′;4′,1″]terphenyl-3-yl)-methanone,
• [1,1′;4′,1″]terphenyl-3″-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid [3-(2-morpholin-4-yl-acetylamino)-phenyl]-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid [4-(2-morpholin-4-yl-acetylamino)-phenyl]-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid [1-(2-bromo-acetyl)-piperidin-4-ylmethyl]-amide,
• 6″-Chloro-[1,1′;4′,1 ″]terphenyl-3″-carboxylic acid (3-methyl-isoxazol-5-yl)-amide,
• 6-Chloro-[1,1′;4′,1 ″]terphenyl-3-carboxylic acid (5-bromo-pyridin-2-yl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (6-morpholin-4-yl-pyridin-3-yl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-dimethylaminomethyl-pyridin-3-yl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-trifluoromethyl-pyridin-3-yl)-amide,
• 6-Fluoro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-methoxy-pyridin-3-yl)-amide,
• 6″-Chloro-2′-fluoro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (2-dimethylamino-ethyl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (3-methoxy-phenyl)-amide,
• [1-(6-Chloro-[1,1′;4′,1″]terphenyl-3-carbonyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (5-methyl-isoxazol-3-yl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-ethenesulfinyl-pyridin-3-yl)-amide,
• 6-Chloro-2″-dimethylaminomethyl-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-methoxy-pyridin-3-yl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (1-carbamimidoyl-piperidin-4-yl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (2-cyano-ethyl)-amide,
• 6″-Chloro-2′-fluoro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid pyrazin-2-ylamide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (2-pyridin-3-yl-ethyl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (4-cyano-phenyl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid [2-(1H-imidazol-4-yl)-ethyl]-pyrrolidin-2-ylmethyl-amide,
• [1-(6-Chloro-[1,1′;4′,1″]terphenyl-3-carbonyl)-piperidin-4-ylmethyl]-carbamic acid tert-butyl ester,
• 6-Methoxy-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-methoxy-pyridin-3-yl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (6-dimethylamino-pyridin-3-yl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid quinolin-8-ylamide,
• 6″-Chloro-2′-fluoro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (piperidin-4-ylmethyl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (3-acetyl-phenyl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid benzo[1,3]dioxol-5-ylamide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (3,4,5-trimethoxy-phenyl)-amide,
• 6-Chloro-4″-methanesulfonyl-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-methoxy-pyridin-3-yl)-amide,
• (6-Chloro-[1,1′;4′,1″]terphenyl3-yl)-[1,4]diazepan-1-yl-methanone,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid pyridin-4-ylamide,
• 6-Hydroxy-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-methoxy-pyridin-3-yl)-amide,
• (3-{[(6-Chloro-[1,1′;4′,1″]terphenyl-3-carbonyl)-amino]-methyl}-benzyl)-carbamic acid tert-butyl ester,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid [4-(acetyl-methyl-amino)-phenyl]-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (2-methanesulfonyl-pyrimidin-5-yl)-amide,
• 6-Chloro-3″,4″,5″-methanesulfonyl-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-methoxy-pyridin-3-yl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-methanesulfinyl-pyridin-3-yl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid cyclopentylamide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid {2-[4-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-ethyl}-amide,
• (6-Chloro-[1,1′;4′,1″]terphenyl-3-yl)-(3-pyridin-4-yl-pyrrolidin-1-y-1)-methanone,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (pyridin-4-ylmethyl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (3-phenyl-[1,2,4]thiadiazol-5-yl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (5-trifluoromethyl-[1,3,4]thiadiazol-2-yl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (4-methanesulfonyl-phenyl)-amide,
• (6-Chloro-[1,1′;4′,1″]terphenyl-3-yl)-piperazin-1-yl-methanone,
• 4-(6-Chloro-[1,1′;4′,1″]terphenyl-3-carbonyl)-piperazine-1-carboxamidine,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (3-chloro-4-methoxy-phenyl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-methyl-1-oxy-pyridin-3-yl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (2,2,2-trifluoro-ethyl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid pyridin-2-ylamide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (4-acetyl-phenyl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (3-methylsulfanyl-phenyl)-amide,
• 4-[(6-Chloro-[1,1′;4′,1″]terphenyl-3-carbonyl)-amino]-benzoic acid methyl ester,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-methoxy-pyrimidin-4-yl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (5-ethyl-[1,3,4]thiadiazol-2-yl)-amide,
• [(6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carbonyl)-phenyl-amino]-acetic acid ethyl ester,
• 4-Methyl-piperazine-1-carboxylic acid 5-(6-methoxy-pyridin-3-ylcarbamoyl)-[1,1′;4′,1″]terphenyl-2-yl ester,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (2-pyridin-3-yl-ethyl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-methoxy-1-oxy-pyridin-3-yl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid benzo[1,2,5]thiadiazol-4-ylamide,
• (4-Aminomethyl-piperidin-1-yl)-(6-chloro-[1,1′;4′,1″]terphenyl-3-yl)-methanone,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-methanesulfonyl-pyridin-3-yl)-amide,
• Methanesulfonic acid 5-(6-methoxy-pyridin-3-ylcarbamoyl)-[1,1′;4′,1″]terphenyl-2-yl ester,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (4-cyanomethyl-phenyl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-ethenesulfonyl-pyridin-3-yl)-amide,
• 1-(6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carbonyl)-piperidine-4-carboxylic acid ethyl ester,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (4-chloro-phenyl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (3,4-dichloro-phenyl)-amide,
• {(2-[(6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carbonyl)-amino]-thiazol-4-yl}-methoxyimino-acetic acid ethyl ester,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (2-chloro-5-cyano-phenyl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (3-ethoxy-phenyl)-amide,
• 4-(6-Chloro-[1,1′;4′,1″]terphenyl-3-carbonyl)-[1,4]diazepane-1-carboxamidine,
• {2-[(6-Chloro-[1,1′;4′,1″]terphenyl-3-carbonyl)-amino]-ethyl }-trimethyl-ammonium,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid isoquinolin-5-ylamide,
• (6-Chloro-[1,1′;4′,1″]terphenyl-3-yl)-(2-pyridin-4-yl-pyrrolidin-1-yl)-methanone,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (pyridin-3-ylmethyl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (3,4-dimethyl-isoxazol-5-yl)-amide,
• 3-[(6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carbonyl)-amino]-pyrazine-2-carboxylic acid methyl ester,
• 6″-Chloro-[1,1′;4′,1 ″]terphenyl-3″-carboxylic acid (3,5-dimethoxy-phenyl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (4-chloro-phenyl)-methyl-amide,
• 4-[(6-Chloro-[1,1′;4′,1″]terphenyl-3-carbonyl)-amino]-piperidine-1-carboxylic acid tertbutyl ester,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (1 H-imidazol-4-ylmethyl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (5-methylsulfanyl-[1,3,4]thiadiazol-2-yl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (pyridin-2-ylmethyl)-amide,
• 2-(6-Chloro-[1,1′;4′,1″]terphenyl-3-carbonyl)-1,2,3,4-tetrahydro-iso-quinoline-3-carboxylic acid [2-(1H-imidazol-4-yl)-ethyl]-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid {5-amino-2-[2-(1H-imidazol-4-yl)-ethylcarbamoyl]-indan-2-yl }-amide,
• 2-(6-Chloro-[1,1′;4′,1″]terphenyl-3-carbonyl)-1,2,3,4-tetrahydro-iso-quinoline-3-carboxylic acid {2-cyclohexyl-1-[2-(1H-imidazol-4-yl)-ethylcarbamoyl]-ethyl }-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid [1,3,4]thiadiazol-2-ylamide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (2-pyridin-4-yl-ethyl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid {1-[2-(1H-imidazol-4-yl)-ethylcarbamoyl]-3-phenyl-propyl}-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (2-chloro-pyridin-3-yl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-chloro-pyridazin-3-yl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (4-methoxy-phenyl)-methyl-amide,
• 3-[(6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carbonyl)-amino]-benzoic acid ethyl ester,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (5-methyl-[1,3,4]thiadiazol-2-yl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (1-aza-bicyclo[2.2.2]oct-3-yl)-amide,
• (6-Chloro-[1,1′;4′,1″]terphenyl-3-yl)-(5-nitro-2,3-dihydro-indol-1-y-l)-methanone,
• 2-[(5″-Chloro-2′-fluoro-[1,1′;4′,1″]terphenyl-2″-carbonyl)-amino]-3-cyclohexyl-propionic acid,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid [2-(2,5-dioxo-pyrrolidin-1-yl)-phenyl]-amide,
• (6″-Chloro-[1,1′;4′,1″]terphenyl-3″-yl)-(4-phenyl-piperazin-1-yl)-methanone,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid benzo[1,3]dioxol-5-yl-ethyl-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid [4-(4-nitro-benzenesulfonyl)-phenyl]-amide,
• 4-[(6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carbonyl)-amino]-benzoic acid ethyl ester,
• {4-[(6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carbonyl)-amino]-phenyl }-acetic acid ethyl ester,
• 2-{2-[(6-Chloro-[1,1′;4′,1″]terphenyl-3-carbonyl)-amino]-4-phenyl-butyrylamino}-4-phenyl-butyric acid,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (3-amino-propyl)-amide,
• 2-[(5″-Chloro-2′-fluoro-[1,1′;4′,1″]terphenyl-2″-carbonyl)-amino]-4-phenyl-butyric acid,
• 3-(6-Chloro-[1,1′;4′,1″]terphenyl-3-carbonyl)-thiazolidine-4-carboxylic acid,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (5-cyclopropyl-[1,3,4]thiadiazol-2-yl)-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (4-cyano-naphthalen-1-yl)-amide,
• 2-{2-[(6-Chloro-[1,1′;4′,1″]terphenyl-3-carbonyl)-amino]-4-phenyl-butyrylamino }-3-cyclohexyl-propionic acid,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid [2-(1H-imidazol-4-yl)-ethyl]-piperidin-4-ylmethyl-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (2-benzenesulfonyl-phenyl)-amide,
• 2-{[2-(6-Chloro-[1,1′;4,′,1″]terphenyl-3-carbonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl]-amino}-3-(1H-imidazol-4-yl)-propionic acid,
• 3-(6-Chloro-[1,1′;4′,1″]terphenyl-3-carbonyl)-thiazolidine-4-carboxylic acid,
• 2-{[2-(6-Chloro-[1,1′;4′,1″]terphenyl-3-carbonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl]-amino}-3-(1H-imidazol4-yl)-propionic acid,
• 6-Fluoro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-methoxy-pyridin-3-yl)-amide,
• (6″-Chloro-[1,1′;4′,1″]terphenyl-3″-yl)-(6-nitro-2,3-dihydro-indol-1-yl)-methanone,
• 8-(6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carbonyl)-4-methyl-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one,
• 1-(6-Chloro-[1,1′;4′,1″]terphenyl-3-carbonyl)-octahydro-indole-2-carboxylic acid,
• 4-[(6-Chloro-[1,1′;4′,1″]terphenyl-3-carbonyl)-amino]-tetrahydro-pyran4-carboxylic acid,
• 1-[(6-Chloro-[1,1′;4′,1″]terphenyl-3-carbonyl)-amino]-4-hydroxy-cyclohexanecarboxylic acid,
• 4-[(6-Chloro-[1,1′;4′,1″]terphenyl-3-carbonyl)-amino]-piperidine-4-carboxylic acid,
• 1-[(6-Chloro-[1,1′;4′,1″]terphenyl-3-carbonyl)-amino]-3-hydroxy-cyclopentanecarboxylic acid,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-hydroxymethyl-pyridin-3-yl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid N′-pyridin-2-yl-hydrazide,
• N′-(6-Chloro-[1,1′;4′,1 ″]terphenyl-3-carbonyl)-hydrazinecarboxylic acid 9H-fluoren-9-ylmethyl ester,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid hydrazide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid [1,2,4]triazol-1-ylamide,
• 2-{2-[(6-Chloro-[1,1′;4′,1″]terphenyl-3-carbonyl)-amino]-4-phenyl-butyrylamino}-3-cyclohexyl-propionic acid,
• 6′-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid (4-methoxy-phenyl)-amide,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (1-{2-cyclohexyl-1-[2-(1H-imidazol-4-yl)-ethylcarbamoyl]-ethylcarbamoyl }-3-phenyl-propyl)-amide,
• 2-{2-[(6-Chloro-[1,1′;4′,1″]terphenyl-3-carbonyl)-amino]-4-phenyl-butyrylamino }-3-(1H-imidazol-4-yl)-propionic acid,
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid [6-(4-methyl-piperazin-1-ylmethyl)-pyridin-3-yl]-amide,
• {2-[(6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carbonyl)-amino]-thiazol-4-yl}-acetic acid ethyl ester,
• 6″-Chloro-[1,1′;4′,1 ″]terphenyl-3″-carboxylic acid cyclopropylmethyl-amide,
• 6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carboxylic acid cyclopropylamide,
• 2-[(6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carbonyl)-amino]-indan-2-carboxylic acid,
• 2-[(6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carbonyl)-methyl-amino]-propionic acid,
• 1-[(6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carbonyl)-amino]-cyclopropanecarboxylic acid,
• 3-[(6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carbonyl)-amino]-propionic acid,
• {3-[(6-Chloro-[1,1 ′;4′,1″]terphenyl-3-carbonyl)-amino]-propyl}-carbamic acid tert-butyl ester,
• 4-{[(6-Chloro-[1,1′;4′,1″]terphenyl-3-carbonyl)-amino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester,
• 2-(6″-Chloro-[1,1′;4′,1″]terphenyl-3″-carbonyl)-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid, and
• 6-Chloro-[1,1′;4′,1″]terphenyl-3-carboxylic acid (6-fluoro-pyridin-3-yl)-amide.