Compositions and methods of treating, reducing and preventing cardiovascular diseases and disorders with polymethoxyflavones
AssigneesThe United States of America as represented by the Secretary of Agriculture, KGK Synergize Inc.
InventorsNajla Guthrie, Elzbieta Maria Kurowska, John A. Manthey
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Abstract
Compositions and methods for the treatment, reduction and/or prevention of cardiovascular diseases and disorders are described. Individuals at high risk for developing or having cardiovascular disease or disorder may be treated with an effective dose of a polymethoxyflavone including limocitrin derivatives, quercetin derivatives, naturally occurring polymethoxyflavones, tocotrienols, and mixtures of these compounds.
Claims7
A method of lowering serum cholesterol, Apo B or LDL cholesterol comprising orally administering to a mammal having elevated levels of serum cholesterol, Apo B or LDL cholesterol an oral pharmaceutical dosage form selected from the group consisting of a tablet or a capsule, said dosage form comprising at least one pharmaceutically acceptable excipient and a combination of
- (a) at least one limocitrin derivative selected from the group consisting of limocitrin-3,7,4′-trimethylether;
- limocitrin-3,5,7,4′-tetramethylether;
- and limocitrin-3,7,4′-trimethylether-5-acetate, and
- (b) at least one quercetin derivative selected from the group consisting of quercetin tetramethylether;
- quercetin 3,5-dimethylether-7,3′,4′-tribenzylether;
- quercetin pentamethylether;
- quercetin-5,7,3′,4′-tetramethylether-3-acetate;
- and quercetin-5,7,3′,4′-tetramethylether;
- to provide about 1-1000 mg/day limocitrin derivative and about 1-1000 mg/day quercetin derivative.
Dependencies are inferred from the claim text.