Compounds for the treatment of inflammatory disorders

A compound represented by Formula (I):

• or a pharmaceutically acceptable salt or ester thereof, wherein:
• ring A is phenyl which is substituted with —Y—R1 and -Z-R2 as shown;
• X is —(C(R3)2)m—;
• T is absent;
• U is absent;
• V is
• which is unsubstituted or substituted with one to four R10 moieties which can be the same or different;
• Y is selected from the group consisting of a covalent bond, —(C(R4)2)n—, —N(R4)—, —C(O)N(R4)—, —N(R4)C(O)—, —N(R4)C(O)N(R4)—, —S(O)2N(R4)—, —N(R4)—S(O)2, —O—, —S—, —C(O)—, —S(O)—, and —S(O)2—;
• Z is selected from the group consisting of a covalent bond, —(C(R4)2)n—, —N(R4)—, —C(O)N(R4)—, —N(R4)C(O)—, —N(R4)C(O)N(R4)—, —S(O)2N(R4)—, —N(R4)—S(O)2—, —O—, —S—, —C(O)—, —S(O)—, and —S(O)2—;
• m is 1;
• n is 1 to 3;
• R1 is selected from the group consisting of H, cyano, —C(O)OH, —C(O)O-alkyl, —C(O)NH2, —C(O)NH(alkyl), —C(O)N(alkyl)2, alkynyl, halogen, alkyl, cycloalkyl, haloalkyl, aryl, heteroaryl, and heterocyclyl, wherein when each of said cycloalkyl, heterocyclyl, aryl and heteroaryl contains two radicals on adjacent carbon atoms, said radicals may optionally be taken together with the carbon atoms to which they are attached to form a five- to eight-membered cycloalkyl, aryl, heterocyclyl or heteroaryl ring;
• wherein each of the R1 alkyl, alkynyl, aryl, heteroaryl, and heterocyclyl, optionally with the five-to eight-membered cycloalkyl, aryl, heterocyclyl or heteroaryl ring is unsubstituted or optionally independently substituted with one to four R20 moieties which can be the same or different;
• with the proviso that when Y is —N(R4)—, —S— or —O—, then R1 is not halogen or cyano;
• R2 is selected from the group consisting of H, cyano, —C(O)OH, —C(O)O-alkyl, —C(O)NH2, —C(O)NH(alkyl), —C(O)N(alkyl)2, alkynyl, halogen, alkyl, cycloalkyl, haloalkyl, aryl, heteroaryl, and heterocyclyl, wherein when each of said cycloalkyl, heterocyclyl, aryl and heteroaryl contains two radicals on adjacent carbon atoms, said radicals may optionally be taken together with the carbon atoms to which they are attached to form a five- to eight-membered cycloalkyl, aryl, heterocyclyl or heteroaryl ring;
• wherein each of the R2 alkyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl, optionally with the five-to eight-membered, aryl, heterocyclyl or heteroaryl ring is unsubstituted or optionally independently substituted with one to four R20 moieties which can be the same or different;
• with the proviso that when Z is —N(R4)—, —S— or —O—, then R2 is not halogen or cyano;
• each R3 is the same of different and is independently selected from the group consisting of H, and alkyl;
• each R4 is the same or different and is independently selected from the group consisting of H, alkyl, cycloalkyl, haloalkyl, hydroxy, -alkylcycloalkyl, -alkyl-N (alkyl)2, heterocyclyl, aryl, and heteroaryl, wherein when each of said cycloalkyl, heterocyclyl, aryl, and heteroaryl contains two radicals on adjacent carbon atoms, said radicals may optionally be taken together with the carbon atoms to which they are attached to form a five- to eight-membered cycloalkyl, aryl, heterocyclyl or heteroaryl ring;
• R10 is selected from the group consisting of hydrogen, cyano, nitro,
• —C(R4)═N—OR4, —OR4, —SR4, —N(R4)2, —S(O)R4, —S(O)2R4, —N(R4)S(O)2R4, —N(R4)—C(O)—R4, —N(R4)—C(O)—N(R4)2, —N(R4)—C(O)—OR4, —OC(O)N(R4)2, —C(O)N(R4)—S(O)2R4, —S(O)2N(R4)—C(O)—R4, —C(O)N(R4)C(O)R4, —C(O)N(R4)C(O)NR4, —S(O)2N(R4)2, —N(R4)—C(═NR4)—N(R4)2, —N(R4)—C(═N—CN)—N(R4)2, -haloalkoxy, —C(O)OR4, —C(O)R4, —C(O)N(R4)2, halogen, alkyl, haloalkyl, aryl, heteroaryl, heterocyclyl, and cycloalkyl, wherein each of the R10 alkyl, aryl, heteroaryl, heterocyclyl, and cycloalkyl is unsubstituted or optionally independently substituted with one to four R30 moieties which can be the same or different;
• or wherein two R10 moieties, when attached to the same or adjacent carbon atoms may optionally be taken together with the carbon atom(s) to which they are attached to form a cycloalkyl, cycloalkenyl, heterocyclyl, aryl, or heteroaryl ring;
• R20 is selected from the group consisting of cyano, nitro,
• —C(R4)═N—OR4, —OR4, —SR4, —N(R4)2, —S(O)R4, —S(O)2R4, —N(R4)S(O)2R4, —N(R4)—C(O)—R4, —N(R4)—C(O)—N(R4)2, —N(R4)—C(O)—OR4, —OC(O)N(R4)2, —C(O)N(R4)—S(O)2R4, —S(O)2N(R4)—C(O)—R4, —C(O)N(R4)C(O)R4, —C(O)N(R4)C(O)NR4, —S(O)2N(R4)2, —N(R4)—C(═NR4)—N(R4)2, —N(R4)—C(═N—CN)—N(R4)2, -haloalkoxy, —C(O)OR4, —C(O)R4, —C(O)N(R4)2, halogen, alkyl, haloalkyl, aryl, heteroaryl, heterocyclyl, and cycloalkyl;
• wherein when each of said R20 aryl, heteroaryl, heterocyclyl and cycloalkyl contains two radicals on adjacent carbon atoms, said radicals may optionally be taken together with the carbon atoms to which they are attached to form a five- to eight-membered cycloalkyl, aryl, heterocyclyl or heteroaryl ring;
• wherein each of said R20 alkyl, aryl, heteroaryl, heterocyclyl, and cycloalkyl, optionally with said five- to eight-membered cycloalkyl, aryl, heterocyclyl or heteroaryl ring is unsubstituted or substituted with one to four moieties selected independently from the group consisting of alkyl, halo, haloalkyl, hydroxy, alkoxy, haloalkoxy, hydroxyalkyl, cyano, nitro, —NH2, —NH(alkyl), and —N(alkyl)2;
• or when two R20 moieties when attached to the same or adjacent carbon atoms may optionally be taken together with the carbon atom(s) to which they are attached to form a cycloalkyl, cycloalkenyl, heterocyclyl, aryl, or heteroaryl ring;
• R30 is selected from the group consisting of cyano, nitro,
• —C(R4)═N—OR4, —OR4, —SR4, —N(R4)2, —S(O)R4, —S(O)2R4, —N(R4)S(O)2R4, —N(R4)—C(O)—R4, —N(R4)—C(O)—N(R4)2, —N(R4)—C(O)—OR4, —OC(O)N(R4)2, —C(O)N(R4)—S(O)2R4, —S(O)2N(R4)—C(O)—R4, —C(O)N(R4)C(O)R4, —C(O)N(R4)C(O)NR4, —S(O)2N(R4)2, —N(R4)—C(═NR4)—N(R4)2, —N(R4)—C(═N—CN)—N(R4)2, -haloalkoxy, —C(O)OR4, —C(O)R4, —C(O)N(R4)2, halogen, alkyl, haloalkyl, aryl, heteroaryl, heterocyclyl, and cycloalkyl;
• wherein when each of said R30 aryl, heteroaryl, heterocyclyl and cycloalkyl contains two radicals on adjacent carbon atoms, said radicals may optionally be taken together with the carbon atoms to which they are attached to form a five- to eight-membered cycloalkyl, aryl, heterocyclyl or heteroaryl ring;
• wherein each of said R30 alkyl, aryl, heteroaryl, heterocyclyl, and cycloalkyl, optionally with said five- to eight-membered cycloalkyl, aryl, heterocyclyl or heteroaryl ring is unsubstituted or substituted with one to four moieties selected independently from the group consisting of alkyl, halo, haloalkyl, hydroxy, alkoxy, haloalkoxy, cyano, nitro, —NH2, —NH(alkyl), and —N(alkyl)2;
• or when two R30 moieties when attached to the same or adjacent carbon atoms may optionally be taken together with the carbon atom(s) to which they are attached to form a cycloalkyl, cycloalkenyl, heterocyclyl, aryl, or heteroaryl ring;
• with the proviso that at least one of conditions (1)-(2) below are satisfied:
• (1) V is substituted with at least one R10 moiety selected from the group consisting of cyano, —C(O)OR4, —C(O)R4, —C(O)N(R4)2, —C(O)N(R4)C(O)R4,—C(O)N(R4)C(O)NR4, —SR4, —S(O)2R4, —N(R4)—C(O)OR4, —OC(O)N(R4)2, —N(R4)C(O)N(R4)2, —N(R4)—C(O)—R4, —S(O)2N(R4)2, —S(O)2N(R4)—C(O)—R4,
• —N(R4)—C(═NR4)—N(R4)2, —N(R4)—C(═N—CN)—N(R4)2, and —C(R4)═N—OR4, wherein each R4 independently is selected from the group consisting of H, alkyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl, wherein when each of said R4 cycloalkyl, heterocyclyl, aryl, and heteroaryl contains two radicals on adjacent carbon atoms, said radicals may optionally be taken together with the carbon atoms to which they are attached to form a five- to eight-membered aryl, heterocyclyl, heteroaryl or cycloalkyl ring;
• (2) each of —Y—R1 and -Z-R2 is independently selected from the group consisting of cyano, —(C(R4)2)n—C(O)OH, —(C(R4)2)n—C(O)O-alkyl, —(C(R4)2)n—C(O)NH2, —(C(R4)2)n—C(O)NH(alkyl), and —(C(R4)2)n—C(O)N(alkyl)2, wherein each R4 independently is H or alkyl;
• and n is 1-3.