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US 7,683,079 B2Granted
4-aminopiperidine derivatives
AssigneeHoffmann-La Roche Inc.
InventorsMarkus Boehringer, Daniel Hunziker, Bernd Kuhn, Bernd Michael Loeffler, Thomas Luebbers, Fabienne Ricklin
Life of this patent
Estimating the term…
Abstract
The present invention relates to compounds of the formula (I) wherein R1 and R2 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP-IV, such as diabetes, non-insulin dependent diabetes mellitus and/or impaired glucose tolerance, obesity, and/or metabolic syndrome or β-cell protection.
Claims11
A compound of the formula I:
- wherein:
- R1 is selected from the group consisting of phenyl, unsubstituted or mono-, di-, or trisubstituted, independently, by lower alkyl, lower alkoxy, phenyl, phenoxy, halogen, or lower halogenalkyl;
- and —(CHR3)m-phenyl, wherein m is 1, 2, or 3 and phenyl being unsubstituted or mono-, di, or trisubstituted, independently, by lower alkyl, halogen, lower halogenalkyl, lower alkoxy, phenyl or phenoxy and wherein R3 is hydrogen, lower alkyl or phenyl;
- R2 is selected from the group consisting of phenyl, unsubstituted or mono-, di-, or trisubstituted, independently, by lower alkyl, halogen, lower halogenalkyl, or lower alkoxy;
- naphthyl, unsubstituted or mono-, di-, or trisubstituted, independently, by lower alkyl, halogen, lower halogenalkyl, or lower alkoxy;
- and pharmaceutically acceptable salts thereof, provided that 1-benzyl-3-(3,4-dimethoxyphenyl)-4-piperidylamine and 1-benzyl-3-phenyl-4-piperidylamine are excluded.
3 more elements
Dependencies are inferred from the claim text.