Tetrahydro-quinolinylurea derivatives

A urea derivative of the formula (I), its tautomeric or stereoisomeric form, or a salt thereof:

• wherein
• m represents 0, 1, 2, or 3;
• p represents 0, 1, 2, or 3;
• —X— represents a bond, —O— or —N(R10)— (wherein R10 is hydrogen or C1-6 alkyl);
• with the proviso that when m is 0, —X— represents a bond,
• RA and RB represent hydrogen, or
• RA and RB together form a carbonyl-group with the carbon-atom to which they are connected,
• R1 represents aryl or heteroaryl
• wherein said aryl and heteroaryl are optionally substituted with one or more substituents independently selected from the group consisting of halogen, nitro, hydroxy, carboxy, amino, C1-6 alkylamino, di(C1-6 alkyl)amino, C3-8 cycloalkylamino, C1-6 alkoxycarbonyl, phenyl (which phenyl is optionally substituted by halogen, nitro, hydroxy, carboxy, amino, C1-6 alkylamino, di(C1-6 alkyl)amino, C3-8 cycloalkylamino, or C1-6 alkoxycarbonyl), benzyl (in which phenyl moiety is optionally substituted by halogen, nitro, hydroxy, carboxy, amino, C1-6 alkylamino, di(C1-6 alkyl)amino, C3-8 cycloalkylamino, or C1-6 alkoxycarbonyl), sulfonamide, C1-6 alkanoyl, C1-6 alkanoylamino, carbamoyl, C1-6 alkylcarbamoyl, cyano, C1-6 alkyl (which alkyl is optionally substituted by cyano, nitro, hydroxy, carboxy, amino, C1-6 alkoxycarbonyl or mono-, di-, or tri-halogen), C1-6 alkoxy (which alkoxy is optionally substituted by mono-, di-, or tri-halogen), phenoxy (in which phenyl moiety is optionally substituted by halogen, nitro, hydroxy, carboxy, amino, C1-6 alkylamino, di(C1-6 alkyl)amino, C3-8 cycloalkylamino, or C1-6 alkoxycarbonyl or C1-6 alkyl), C1-6 alkylthio (which alkylthio is optionally substituted by mono-, di-, or tri-halogen), C3-8 cycloalkyl, and heterocycle;
• and
• R2 represents C1-6alkylcarbonyl, C1-6alkylsulfonyl, hydrogen, hydroxy,
• aryl, heteroaryl, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-8cycloalkyl, arylsulfonyl, or heteroarylsulfonyl,
• wherein
• said alkyl, alkenyl or alkynyl are optionally substituted by mono-, di-, or tri-halogen, hydroxy, carboxyl, nitro, cyano, C1-6alkoxy, C1-6alkoxycarbonyl, C3-8cycloalkyl, amino, N-(C1-6alkyl)amino, N,N-di(C1-6alkyl)amino, N-(aryl)amino, N-(heteroaryl)amino, carbamoyl, N-(C1-6alkyl)aminocarbonyl, or N,N,-di(C1-6alkyl)aminocarbonyl, and
• said cycloalkyl, aryl, heteroaryl, aryl moiety of said arylsulfonyl, or heteroaryl moiety of said heteroarylsulfonyl are optionally substituted by
• mono-, di-, or tri-halogen, hydroxy, carboxyl, cyano, nitro, (C1-6alkoxy)carbonyl, C3-8cycloalkyl, amino, N-(C1-6alkyl)amino, N,N-di(C1-6alkyl)amino, N-(aryl)amino, N-(heteroaryl)amino, carbamoyl, N-(C1-6alkyl)aminocarbonyl, N,N-di(C1-6alkyl)aminocarbonyl, C1-6alkyl optionally substituted by mono-, di-, or tri-halogen, or C1-6alkoxy optionally substituted by mono-, di-, or tri-halogen.