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US 7,683,073 B2Granted
Isoquinoline-1,3,4-trione compounds, the synthetic method and the use thereof
AssigneeShanghai Institute of Materia Medica, Chinese Academy of Sciences
InventorsFajun Nan, Jia Li, Yihua Chen, Yahui Zhang, Min Gu, Huajie Zhang
Life of this patent
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Abstract
The invention relates to various substituted isoquinoline-1,3,4-trione, the synthetic method thereof and the use for treating neurodegenerative diseases, especially as the medicine for Alzheimer's disease, apoplexy and brain ischemic injuries.
Claims9
An isoquinoline-1,3,4-trione compound represented having the following structural formula:
- wherein, the substituent R1 is optionally selected from the group consisting of;
- alkyl;
- hydroxyl;
- alkyl substituted by the groups including halogen, alkoxyl or hydroxyl;
- alkoxyl or alkylamino substituted by the groups including halogen, alkoxyl or hydroxyl;
- C2-C6 alkenyl substituted by oxygen or amine;
- C3-C6 cycloalkyl;
- substituted aryl;
- benzyl;
- alkanoyl;
- alkanoyl substituted by the groups including halogen, alkoxyl or hydroxyl;
- C2-C6 enoyl;
- C3-C6 cycloalkanoyl;
- tert-butoxycarbonyl;
- benzoyl;
- benzoyl substituted by one, two or three groups including alkylamino;
- benzylacyl;
- benzylacyl substituted by one, two or three groups including alkylamino;
- thienoyl;
- adamantylcarbonyl;
- mandeloyl;
- alkoxyl;
- alkylamino;
- cycloalkoxyl;
- cycloalkylamino;
- amino;
- acylamino;
- alkyloxycarbonyl;
- cycloalkoxycarbonyl;
- alkanoyloxy;
- alkanoylamino;
- cycloalkyanoyloxy;
- cycloalkanoylamino;
- ureido;
- urenylene;
- alkanoyl;
- nitro;
- carboxyl;
- and
- substituent R3 is optionally selected from the group consisting of H;
- alkyl;
- hydroxyl;
- alkyl substituted by the groups including halogen, alkoxyl or hydroxyl;
- alkoxyl or alkylamino substituted by the groups including halogen, alkoxyl or hydroxyl;
- C2-C6 alkenyl substituted by oxygen or amine;
- C3-C6 cycloalkyl;
- substituted aryl;
- benzyl;
- alkanoyl;
- alkanoyl substituted by the groups including halogen, alkoxyl or hydroxyl;
- C2-C6 enoyl;
- C3-C6 cycloalkanoyl;
- tert-butoxycarbonyl;
- benzoyl;
- benzoyl substituted by one, two or three groups including alkylamino;
- benzylacryl;
- benzylacrylcarbonyl substituted by one, two or three groups including alkylamino;
- thienoyl;
- adamantylcarbonyl;
- mandeloyl;
- alkoxyl;
- alkylamino;
- cycloalkoxyl;
- cycloalkylamino;
- amino;
- acylamino;
- alkyloxycarbonyl;
- cycloalkoxycarbonyl;
- alkanoyloxy;
- alkanoylamino;
- cycloalkyanoyloxy;
- cycloalkanoylamino;
- ureido;
- urenylene;
- alkanoyl;
- nitro;
- and carboxyl;
- Z is CH2, O or NH;
- W is O or H2;
- n=1, 2, 3, 4, or 5.
- X is CH2, NH, O, or S;
- and
- Y is CH, or N.
80 more elements
A compound represented having the following structural formula:
- wherein, the substituent R1 is optionally selected from the group consisting of:
- H;
- alkyl;
- hydroxyl;
- alkyl substituted by the groups
- including halogen, alkoxyl or hydroxyl;
- alkoxyl or alkylamino substituted by the groups including halogen, alkoxyl or hydroxyl;
- C2-C6 alkenyl substituted by oxygen or amine;
- C3-C6 cycloalkyl;
- substituted aryl;
- or benzyl;
- X is CH2, NH, O, or S;
9 more elements
An isoquinoline-1,3,4-trione compound selected from the group consisting of
Dependencies are inferred from the claim text.