Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid
AssigneeTaro Pharmaceuticals Industries, Ltd.
InventorsDaniella Gutman, Barrie Levitt, Daniel Moros, Avraham Yacobi, Howard Rutman
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Abstract
The present invention relates to a composition and a method of delivering a barbituric acid derivative to the central nervous system of a mammal in need of treatment for neurological conditions. In particular, the present invention relates to a method of administering an oral dosage form of a sodium salt of 5,5-diphenyl barbituric acid to enhance the bioavailability of 5,5-diphenyl barbituric acid and brain delivery of same.
Claims49
A method of improving bioavailability of 5,5-diphenyl barbituric acid in a mammal in need of anti-convulsant treatment, comprising the step of administering to the mammal an oral dosage form that comprises an isolated sodium salt of 5,5-diphenyl barbituric acid, wherein the oral dosage form is solid or a suspension.
A therapeutic method comprising administering an isolated sodium salt of 5,5-diphenyl barbituric acid to a mammal orally in a solid dosage form.
A method of achieving a therapeutic blood level of 5,5-diphenyl barbituric acid in a mammal in need of anti-convulsant treatment, comprising the step of orally administering to the mammal an oral dosage form that comprises isolated sodium salt of 5,5-diphenyl barbituric acid in an amount at least 30% less than the amount of 5,5-diphenyl barbituric acid required to achieve the same therapeutic blood level, wherein the oral dosage form is solid or a suspension.
Dependencies are inferred from the claim text.