Inhibitors of Bruton's tyrosine kinase

A compound of Formula I,

• wherein:
• R is H, -R1, -R1-R2-R3, -R1-R3, or -R2-R3;
• R1 is aryl, heteroaryl, cycloalkyl, or heterocycloalkyl, and is optionally substituted with one or more lower alkyl, hydroxy, hydroxy lower alkyl, lower alkoxy, halo, nitro, amino, amido, cyano, oxo, or halo-lower alkyl;
• R2 is —C(═O), —C(═O)O, —C(═O)NR2, —NHC(═O)O, [[,]]—C(═NH)NR2, or —S(═O)2;
• R2′ is H or lower alkyl;
• R3 is H or R4;
• R4 is lower alkyl, amino, aryl, arylalkyl, alkylaryl, heteroaryl, allyl heteroaryl, heteroaryl alkyl, cycloalkyl, alkyl cycloalkyl, cycloalkyl alkyl, heterocycloalkyl, alkyl heterocycloalkyl, or heterocycloalkyl alkyl, and is optionally substituted with one or more lower alkyl, hydroxy, lower alkoxy, hydroxy lower alkyl, hydroxy lower alkoxy, lower alkyl sulfonyl, lower alkyl sulfonamido, carbamate, carboxy, ester, amido, acyl, halo, nitro, amino, cyano, oxo, or halo-lower alkyl;
• X is CH or N;
• Y1 is H, lower alkyl, or lower haloalkyl;
• each Y2 is independently halogen, oxime, or lower alkyl, wherein lower alkyl is optionally substituted with one or more substituents selected from the group consisting of hydroxy, lower alkoxy, lower haloalkoxy, lower haloalkyl, carboxy, amino, and halogen;
• n is 0, 1, 2, or 3;
• Y3 is halogen or lower alkyl, wherein lower alkyl is optionally substituted with one or more substituents selected from the group consisting of hydroxy, lower alkoxy, amino, and halogen;
• m is 0 or 1;
• Y4 is Y4a, Y4b,Y4c, or Y4d;
• Y4a is H or halogen;
• Y4b is lower alkyl, optionally substituted with one or more substituents selected from the group consisting of lower haloalkyl, halogen, hydroxy, amino, cyano, and lower alkoxy;
• Y4c is lower cycloalkyl, optionally substituted with one or more substituents selected from the group consisting of lower alkyl, lower haloalkyl, halogen, hydroxy, amino, cyano, and lower alkoxy;
• and
• Y4d is amino, optionally substituted with one or more lower alkyl, alkoxy lower alkyl, or hydroxy lower alkyl;
• or a pharmaceutically acceptable salt thereof.