Therapeutic agents useful for treating pain

A compound of formula:

• or a pharmaceutically acceptable salt thereof, wherein Ar1 is
• Ar2 is
• V is N or CH;
• X is O or S;
• R1 is —H, -halo, -(C1-C4)alkyl, —NO2, —CN, —OH, —OCH3, —NH2, C(halo)3, —CH(halo)2, or —CH2(halo);
• each R2 is independently:
• (a) -halo, —CN, —OH, —NO2, or —NH2,
• (b) -(C1-C10)alkyl, -(C2-C10)alkenyl, -(C2-C10)alkynyl, -(C3-C10)cycloalkyl, -(C8-C14)bicycloalkyl, -(C8-C14)tricycloalkyl, -(C5-C10)cycloalkenyl, -(C8-C14)-bicycloalkenyl, -(C8-C14)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R5 groups, or
• (c) -phenyl, -naphthyl, -(C14)aryl or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R6 groups;
• each R3 is independently:
• (a) -halo, —CN, —OH, —NO2, or —NH2,
• (b) -(C1-C10)alkyl, -(C2-C10)alkenyl, -(C2-C10)alkynyl, -(C3-C10)cycloalkyl, -(C8-C14)bicycloalkyl, -(C8-C14)tricycloalkyl, -(C5-C10)cycloalkenyl, -(C8-C14)-bicycloalkenyl, -(C8-C14)tricycloalkenyl, -(3- to 7-membered)heterocycle, or -(7- to 10-membered)bicycloheterocycle, each of which is unsubstituted or substituted with one or more R5 groups, or
• (c) -phenyl, -naphthyl, -(C14)aryl or -(5- to 10-membered)heteroaryl, each of which is unsubstituted or substituted with one or more R6 groups;
• R4 is —H or -(C1-C6)alkyl;
• each R5 is independently —CN, —OH, -(C1-C6)alkyl, -(C2-C6)alkenyl, -(C2-C6)alkynyl, -halo, —N3, —NO2, —N(R7)2, —CH═NR7, —NR7OH, —OR7, —COR7, —C(O)OR7, —OC(O)R7, —OC(O)OR7, —SR7, —S(O)R7, or —S(O)2R7;
• each R6 is independently -(C1-C6)alkyl, -(C2-C6)alkenyl, -(C2-C6)alkynyl, -(C3-C8)cycloalkyl, -(C5-C8)cycloalkenyl, -phenyl, -(3- to 5-membered)heterocycle, —C(halo)3, —CH(halo)2, —CH2(halo), —CN, —OH, -halo, —N3, —NO2, —N(R7)2, —CH═NR7, —NR7OH, —OR7, —COR7, —C(O)OR7, —OC(O)R7, —OC(O)OR7, —SR7, —S(O)R7, or —S(O)2R7;
• each R7 is independently —H, -(C1-C6)alkyl, -(C2-C6)alkenyl, -(C2-C6)alkynyl, -(C3-C8)cycloalkyl, -(C5-C8)cycloalkenyl, -phenyl, -(3- to 5-membered)heterocycle, —C(halo)3, —CH(halo)2, or CH2(halo);
• each R8 is independently —H, -(C1-C10)alkyl, -(C2-C6)alkenyl, -(C2-C6)alkynyl, -(C3-C8)cycloalkyl, -(C5-C8)cycloalkenyl, -phenyl, —C(halo)3, —CH(halo)2, CH2(halo), —CN, —OH, -halo, —N3, —NO2, —N(R7)2, —CH═NR7, —NR7OH, —OR7, —COR7, —C(O)OR7, —OC(O)R7, —OC(O)OR7, —SR7, —S(O)R7, —S(O)2R7, —R7OR7, —R7COR7, —R7C(O)OR7, —R7OC(O)R7, —R7OC(O)OR7, —R7OC(O)R7, —R7S(O)R7, 13 R7S(O)2R7, —C(halo)2C(halo)3, —C(halo)2CH(halo)2, —CH(C(halo)3)2, —CH(C(halo)3)(CH3), —OC(halo)2C(halo)3, —OC(halo)2CH(halo)2, —OCH(C(halo)3)2, —OCH(C(halo)3)(CH3), —C(OH)(CF3)2, -(C1-C10)alkyl, or -(3- to 7-membered)heterocycle;
• each R11 is independently —CN, —OH, -(C1-C6)alkyl, -(C2-C6)alkenyl, -(C2-C6)alkynyl, -halo, —N3, —NO2, —N(R7)2, —CH═NR7, —NR7OH, —OR7, —COR7, —C(O)OR7, —OC(O)R7, or —OC(O)OR7;
• each halo is independently —F, —Cl, —Br, or —I;
• m is 0 or 1 and when m is 1, R3 is attached to the 2-, 3-, 5-, or 6-position of the cyclo(hetero)alkenyl ring;
• p is an integer ranging from 0 to 2;
• q is an integer ranging from 0 to 6;
• r is an integer ranging from 0 to 5;
• and
• s is an integer ranging from 0 to 4.