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US 7,683,058 B2Granted
Substituted pyrimidine derivatives
AssigneeH. Lundbeck A/S
InventorsNikolay Khanzhin, Daniel Rodriguez Greve, Mario Rottländer
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Abstract
The present invention relates to pyrimidine derivatives of the general formula I or salts thereof and their use.
Claims5
A compound selected from the group consisting of:
- N-[4-Amino-6-methyl-2-(4-trifluoromethylbenzylamino)-pyrimidin-5-yl]-2-cyclopentylacetamide,
- N-[4-Amino-6-methyl-2-(4-trifluoromethylbenzylamino)-pyrimidin-5-yl]-3,3-dimethylbutyramide,
- N-[4-Amino-6-methyl-2-(4-trifluoromethylbenzylamino)-pyrimidin-5-yl]-2-(4-fluorophenyl)-acetamide,
- Hexanoic acid [4-amino-6-methyl-2-(4-trifluoromethylbenzylamino)-pyrimidin-5-yl]-amide,
- N-[4-Amino-6-methyl-2-(4-trifluoromethylbenzylamino)-pyrimidin-5-yl]-2-(3-chlorophenyl)-acetamide,
- 2-Cyclopentyl-N-(4,6-dimethyl-2-morpholin-4-yl-pyrimidin-5-yl)-acetamide,
- N-(4,6-Dimethyl-2-morpholin-4-yl-pyrimidin-5-yl)-3,3-dimethylbutyramide,
- N-(4,6-Dimethyl-2-morpholin-4-ylpyrimidin-5-yl)-2-(4-fluorophenyl)-acetamide,
- 2-(3,4-Difluorophenyl)-N-(4,6-dimethyl-2-morpholin-4-ylpyrimidin-5-yl)-acetamide,
- N-(4,6-Dimethyl-2-morpholin-4-ylpyrimidin-5-yl)-2-(3-fluorophenyl)-acetamide and
- Hexanoic acid (4,6-dimethyl-2-morpholin-4-ylpyrimidin-5-yl)-amide;
- or a pharmaceutically acceptable salt thereof.
9 more elements
A compound having the general formula I:
- wherein:
- q is 0 or 1;
- R1 and R2 taken together with the nitrogen to which they are attached form a 5 to 7 membered ring optionally containing a further heteroatom that is oxygen;
- R3 and R4 are independently selected from hydrogen, halogen, cyano, amino, C1-6-alk(en/yn)yl, C3-8-cycloalk(en)yl, halo-C1-6-alk(en/yn)yl, halo-C3-8-cycloalk(en)yl, C1-6-alk(en/yn)yloxy, C3-5-cycloalk(en)yloxy, C3-5-cycloalk(en)yl-C1-6-alk(en/yn)yl oxy, halo-C1-6-alk(en/yn)yloxy, halo-C3-8-cycloalk(en)yloxy and halo-C3-5-cycloalk(en)yl-C1-6-alk(en/yn)yloxy, provided that R3 and R1 are not both hydrogen;
- R5 is selected from the group consisting of C1-10-alk(en/yn)yl, C3-8-cycloalk(en)yl-C1-6-alk(en/yn)yl, optionally substituted aryl-C1-6-alk(en/yn)yl and optionally substituted aryl;
- or a pharmaceutically acceptable salt thereof.
3 more elements
Dependencies are inferred from the claim text.