Crystalline polymorph of bazedoxifene acetate
AssigneeWyeth
InventorsKadum A. Ali, Pietro Allegrini, Aldo Belli, Roberto Brescello, Vincenzo Cannata, Malama K. Chibwe, Livius Cotarca, Shridhar G. Gangolli, Carl E. Longfellow, Giorgio Soriato, Massimo Verzini
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Abstract
The present invention is directed to a crystalline polymorph of bazedoxifene acetate, compositions containing the same, preparations thereof, and uses thereof.
Claims41
A crystalline polymorph (form B) of bazedoxifene acetate having a powder X-ray diffraction pattern comprising characteristic peaks, in terms of 2θ, at about 13.3° and about 20.8°.
A process for increasing the proportion of bazedoxifene acetate form B in a composition comprising a mixture of form A and form B, said process comprising combining solvent comprising ethanol with said composition to form a mixture, wherein said mixture is maintained at or above a temperature of about 25° C. for a time and under conditions suitable for increasing the proportion of Form B in said composition.
Dependencies are inferred from the claim text.