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US 7,683,048 B2Granted
Polymorphis of a known thiophenecarboxylic acid dodecahydrocyclopenta (a) phenanthrenyl ester
AssigneeNovartis AG
InventorsGuido Jordine, Michael Mutz
Life of this patent
Estimating the term…
Abstract
Polymorphic crystal forms of 3-methylthiophene-2-carboxylic acid (6S,9R,10S,11S,13S,16R, 17R)-9-chloro-6-fluoro-11-hydroxy-17-methoxycarbonyl-10,13,16-trimethyl-3-oxo-6,7,8,9,10, 11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl ester. The crystal forms possess anti-inflammatory activity and have very good stability. Methods for preparing the crystal forms are also described.
Claims10
A compound of formula I
- in a crystal form B that has a melting point, by Differential Scanning Calorimetry, of about 270° C. with simultaneous decomposition, at a heating rate of 20° C./min and the following characteristic diffraction lines (2θ in angular degrees±0.2°) in the X-ray diffraction pattern thereof:
- 7.2°, 9.3°, 12.0°, 12.8°, 13.1°, 14.5°, 17.4°, 20.4°, 23.2° and 25.8°.
Dependencies are inferred from the claim text.