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US 7,683,045 B2Granted
Class of γδ T cells activators and use thereof
AssigneeInnate Pharma
InventorChristian Belmant
Life of this patent
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Abstract
The present invention relates to a new class of compounds having γδ T cells activating properties referred to herein as angelyl or tiglyl phosphoesters, compositions comprising any of these compounds and methods for regulating an immune response in a subject comprising the step of administering these compounds.
Claims42
A γδ T cell activator of formula:
- wherein Cat+ represents one or more cation, that can be the same or different, selected from proton(s), organic cation(s) or mineral cation(s);
- m is an integer from 1 to 3;
- B is O, NH;
- A is O, NH, CHF, CF2 or CH2;
- W is C—R6 or N;
- R7 is a (C1-C3)alkyl group, CF3, CH2F or CF2H;
- R3, R4, and R6 identical or different, are a hydrogen or a (C1-C3)alky group;
- R5 is an (C2-C3)acyl, an aldehyde, an (C1-C3)alcohol, or an (C2-C3)ester;
- and,
- Y is O−Cat+, a C1-C3 alky group, or a group -A-R, wherein R is a linear, branched, or cyclic, aromatic or non-aromatic, saturated or unsaturated, C1-C50 hydrocarbon group, wherein said hydrocarbon group can be interrupted by at least one heteroatom or is uninterrupted and said hydrocarbon group comprises an alkyl, an alkylenyl or an alkynyl which can be substituted by one or several substituents selected from the group consisting of:
- an alkyl, an alkylenyl, an alkylnyl, an epoxyalkyl, an aryl, an heterocycle, an alkoxy, an acyl, an alcohol, a carboxylic group (—COOH), an ester, an amine, an amino group (—NH2), an amide (—CONH2), an imine, a nitrile, an hydroxyl (—OH), a aldehyde group (—CHO), an halogen, an halogenoalkyl, a thiol (—SH), a thioalkyl, a sulfone, a sulfoxide, and a combination thereof.
8 more elements
A composition comprising a γδ T cell activator of formula:
- wherein Cat− represents one or more cation, that can be the same or different, selected from proton(s), organic cation(s) or mineral cation(s);
- m is an integer from 1 to 3;
- B is O, NH;
- A is O, NH, CHF, CF2 or CH2;
- W is C—R6 or N;
- R7 is a (C1-C3)alkyl group, or CF3, CH2F or CF2H;
- R3, R4, and R6 identical or different, are a hydrogen or a (C1-C3)alky group;
- R5 is an (C2-C3)acyl, an aldehyde, an (C1-C3)alcohol, or an (C2-C3)ester;
- and
- Y is O−Cat+, a C1-C3 alkyl group, or a group -A-R, wherein R is a linear, branched, or cyclic, aromatic or non-aromatic, saturated or unsaturated, C1-C50 hydrocarbon group, wherein said hydrocarbon group can be interrupted by at least one heteroatom or is uninterrupted and said hydrocarbon group comprises an alkyl, an alkylenyl or an alkynyl which can be substituted by one or several substituents selected from the group consisting of:
- an alkyl, an alkylenyl, an alkylnyl, an epoxyalkyl, an aryl, an heterocycle, an alkoxy, an acyl, an alcohol, a carboxylic group (—COOH), an ester, an amine, an amino group (—NH2), an amide (—CONH2), an imine, a nitrile, an hydroxyl (—OH), a aldehyde group (—CHO), an halogen, an halogenoalkyl, a thiol (—SH), a thioalkyl, a sulfone, a sulfoxide, and a combination thereof.
8 more elements
Dependencies are inferred from the claim text.