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US 7,683,043 B2Granted
Creatine phosphate analog prodrugs, compositions and uses thereof
AssigneeXenoPort, Inc.
InventorsNoa Zerangue, Qingzhi Gao, William J. Dower
Life of this patent
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Abstract
Membrane permeable prodrugs of creatine phosphate analogs, pharmaceutical compositions comprising membrane permeable prodrugs of creatine phosphate analogs, and methods of treating diseases such as ischemia, heart failure, and neurodegenerative disorders comprising administering prodrugs of creatine phosphate analogs, or pharmaceutical compositions thereof are disclosed.
Claims26
A compound of Formula (II):
- a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of any of the foregoing, wherein:
- n is selected from 1 and 2;
- Y and Z are independently selected from Formula (1), Formula (2), and Formula (3):
- each X is independently selected from O and S;
- each R1 and R2 is independently selected from hydrogen, C1-8 alkyl, substituted C1-8 alkyl, C1-8 heteroalkyl, substituted C1-8 heteroalkyl, C3-12 cycloalkyl, substituted C3-12 cycloalkyl, C4-20 cycloalkylalkyl, substituted C4-20 cycloalkylalkyl, C4-20 heterocycloalkylalkyl, substituted C4-20 heterocycloalkylalkyl, C5-12 aryl, substituted C5-12 aryl, C5-12 heteroaryl, substituted C5-12 heteroaryl, C6-20 arylalkyl, substituted C6-20 arylalkyl, C6-20 heteroarylalkyl, and substituted C6-20 heteroarylalkyl;
- each R4 is independently selected from C1-8 alkyl, substituted C1-8 alkyl, C1-8 heteroalkyl, substituted C1-8 heteroalkyl, C3-12 cycloalkyl, substituted C3-12 cycloalkyl, C4-20 cycloalkylalkyl, substituted C4-20 cycloalkylalkyl, C4-20 heterocycloalkylalkyl, substituted C4-20 heterocycloalkylalkyl, C5-12 aryl, substituted C5-12 aryl, C5-12 heteroaryl, substituted C5-12 heteroaryl, C6-20 arylalkyl, substituted C6-20 arylalkyl, C6-20 heteroarylalkyl, and substituted C6-20 heteroarylalkyl;
- and
- each R6 is independently selected from hydrogen, C1-8 alkyl, substituted C1-8 alkyl, C5-12 cycloalkyl, substituted C5-12 cycloalkyl, C5-12 aryl, and C5-12 substituted aryl;
- R3 is selected from hydrogen, C1-8 alkyl, substituted C1-8 alkyl, C1-8 heteroalkyl, substituted C1-8 heteroalkyl, C5-12 cycloalkyl, substituted C5-12 cycloalkyl, C6-20cycloalkylalkyl, substituted C6-20 cycloaklkyl, C6-20 heterocycloalkylalkyl, substituted C6-20 heterocycloalkylalkyl, C5-12 aryl, substituted C5-12 aryl, C5-12 heteroaryl, substituted C5-12 heteroaryl, C6-20 arylalkyl, substituted C6-20 arylalkyl, C6-20 heteroarylalkyl, and substituted C6-20 heteroarylalkyl;
- each R7 and R8 is independently selected from hydrogen, C1-8 and substituted C1-8 alkyl;
- and
- R9 is selected from hydrogen, C1-8 alkyl, substituted C1-8 alkyl, C1-8 heteroalkyl, and substituted C1-8 heteroalkyl.
9 more elements
Dependencies are inferred from the claim text.