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US 7,682,838 B2Granted
Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsShan X. Wang, Robert L. White, Chris D. Webb, Guanxiong Li
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Abstract
Magnetic nanoparticles and methods for their use in detecting biological molecules are disclosed. The magnetic nanoparticles can be attached to nucleic acid molecules, which are then captured by a complementary sequence attached to a detector, such as a spin valve detector or a magnetic tunnel junction detector. The detection of the bound magnetic nanoparticle can be achieved with high specificity and sensitivity.
Claims9
A magnetic tunnel junction detector array, said array comprising:
- a plurality of detection sites, wherein each detection site of said plurality comprises:
- a magnetic tunnel junction detector comprising:
- a bottom electrode;
- a tunnel barrier layer;
- and
- a double-layer top electrode comprising:
- a first thin layer, wherein said first thin layer is from about 1 nm to about 10 nm in thickness;
- and
- a second layer contacting said first layer, wherein said second layer is a conductive layer and comprises an aperture exposing a part of said first layer,
- wherein said tunnel barrier layer is disposed between bottom electrode and said double-layer top electrode;
- and
- a binding molecule covalently bonded to said magnetic tunnel junction detector.
9 more elements
Dependencies are inferred from the claim text.