Methods for covalently immobilizing anti-thrombogenic material into a coating on a medical device
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorsEugene T. Michal, Ni Ding, Christopher J. Buchko
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Abstract
The present invention is directed to a medical device having a polymerized base coat layer for the immobilization of an anti-thrombogenic material, such as heparin, thereon. The binding coat layer is comprised of various chemically functional groups which are stable and allow for the immobilization of the anti-thrombogenic material thereto. Methods for immobilizing the anti-thrombogenic material within the base coat layer posited on a surface of the medical device are also provided.
Claims16
A method for immobilizing an anti-thrombogenic material into a coating comprising a base coat layer posited on a surface of an implantable medical device for use within a mammalian body, comprising:
- preparing a base coat mixture comprising a binding material, a grafting material, a photoinitiator, and a solvent;
- applying the base coat mixture directly to the implantable medical device;
- polymerizing the base coat mixture to form the base coat layer on the medical device by photopolymerization;
- applying a formulation comprising the anti-thrombogenic material to the surface of the base coat layer;
- and
- immobilizing the anti-thrombogenic material directly to chemically functional groups in the binding material within the base coat layer on the surface of the medical device,
- wherein the binding material of the base coat layer is selected from the group consisting of acetoacetoxy compounds, and
- wherein the anti-thrombogenic material is selected from the group consisting of glycosaminoglycans, superoxide dismutase mimetic (SODm) grafted to heparin, and combinations thereof.
A method for end-immobilizing an anti-thrombogenic material into a coating comprising a base coat layer posited on a surface of an implantable medical device for use within a mammalian body, comprising:
- preparing a base coat mixture comprising a binding material, a grafting material, a photoinitiator, and a solvent;
- applying the base coat mixture directly to the implantable medical device;
- polymerizing the base coat mixture to form the base coat layer on the medical device by photopolymerization;
- applying a formulation comprising the anti-thrombogenic material to the surface of the base coat layer;
- and
- end-immobilizing the anti-thrombogenic material, through a group that terminates the anti-thrombogenic material, directly to chemically functional groups in the binding material within the base coat layer on the surface of the medical device,
- wherein the binding material of the base coat layer is selected from the group consisting of acetoacetoxy compounds, and
- wherein the anti-thrombogenic material is selected from the group consisting of glycosaminoglycans, superoxide dismutase mimetic (SODm) grafted to heparin, and combinations thereof.
A method for immobilizing an anti-thrombogenic material into a coating comprising a base coat layer posited on a surface of an implantable medical device for use within a mammalian body, comprising:
- preparing a base coat mixture comprising a binding material, a grafting material, a photoinitiator, and a solvent;
- applying the base coat mixture directly to the implantable medical device;
- polymerizing the base coat mixture to form the base coat layer on the medical device by photopolymerization;
- applying a formulation comprising the anti-thrombogenic material to the surface of the base coat layer;
- and
- immobilizing the anti-thrombogenic material directly to chemically functional groups in the binding material within the base coat layer on the medical device,
- wherein the binding material of the base coat layer is selected from the group consisting of acetoacetoxy compounds, and
- wherein the anti-thrombogenic material comprises a superoxide dismutase mimetic (SODm), grafted to heparin.
Dependencies are inferred from the claim text.