Methods for forming polymeric coatings on stents
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorsNi Ding, Deborra Sanders Millare, Syed F. A. Hossainy
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Abstract
A method is provided for forming a polymeric coating on a stent. The method can comprise applying a prepolymer or a combination of prepolymers to the stent and initiating polymerization to form a polymeric coating on the stent. The coating material can optionally contain a biologically active agent or combination of agents.
Claims16
A method of forming a polymeric coating on a stent, comprising:
- (a) spraying a radially expandable stent with a coating fluid, the coating fluid comprising a prepolymer, a bioactive agent mixed with the prepolymer, and an additive for increasing the viscosity of the fluid;
- and
- (b) causing the prepolymer to react to form a polymeric coating on the stent;
- wherein the prepolymer comprises a hydrophobic macromer comprising structural units of a polymer, wherein the bioactive agent is contained in the polymeric coating, and wherein the polymer forming the coating is a thermoplastic linear polymer comprising a multiple repetition of units derived from the macromer or combination of macromers in linear sequence and is free from cross-linked fragments.
A method of forming a polymeric coating for a stent, comprising:
- (a) applying polycaprolactone diacrylate to the stent;
- and
- (b) polymerizing the polycaprolactone diacrylate to form a polymeric coating for the stent;
- wherein the polymeric coating comprises a thermoplastic linear polymer comprising a multiple repetition of units derived from the polycaprolactone diacrylate in linear sequence and is free from cross-linked fragments.
A method of forming a polymeric coating on a stent, comprising:
- (a) spraying a radially expandable stent with a coating fluid, the coating fluid comprising a prepolymer and a bioactive agent mixed with the prepolymer;
- (b) causing the prepolymer to react to form a polymer;
- and
- (c) adding a non-solvent to precipitate the polymer formed by the reaction of the prepolymer such that a polymeric coating is formed on the stent;
- wherein the prepolymer comprises a hydrophobic macromer comprising structural units of the polymer, wherein the bioactive agent is contained in the polymeric coating, and wherein the polymer forming the coating is a thermoplastic linear polymer comprising a multiple repetition of units derived from the macromer or combination of macromers in linear sequence and is free from cross-linked fragments.
A method of forming a polymeric coating on a stent, comprising:
- (a) spraying a radially expandable stent with a coating fluid, the coating fluid comprising a prepolymer, a bioactive agent mixed with the prepolymer, and a wetting fluid;
- and
- (b) causing the prepolymer to react to form a polymeric coating on the stent;
- wherein the prepolymer comprises a hydrophobic macromer comprising structural units of a polymer, wherein the bioactive agent is contained in the polymeric coating, and wherein the polymer forming the coating is a thermoplastic linear polymer comprising a multiple repetition of units derived from the macromer or combination of macromers in linear sequence and is free from cross-linked fragments.
A method of forming a polymeric coating for a stent, comprising:
- (a) applying n-butyl methacrylate and an initiator to the stent;
- and
- (b) polymerizing the n-butyl methacrylate to form a poly(n-butylmethacrylate) polymeric coating for the stent;
- wherein the polymeric coating comprises a thermoplastic linear polymer.
Dependencies are inferred from the claim text.