Efficient method for producing compositions enriched in total phenols
AssigneePhenolics, LLC
InventorsGerald T. Gourdin, Steven L. Richheimer, Michael S. Tempesta, David T. Bailey, Rebecca L. Nichols, F. Joseph Daugherty, Delano R. Freeberg
Life of this patent
Estimating the term…
Abstract
A product made by a process which results in compositions enriched in total phenols includes purification steps not involving the addition of bisulfite ions. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols, total phenol concentration >12% and exhibiting in vitro COX-2 inhibitory activity enhanced by a factor of at least 2.5 over a standard aspirin dose of 660 μg/mL.
Claims11
A method of producing a composition enriched in total phenols prepared without the addition of bisulfite ions comprising the steps of:
- non-selectively extracting phenols from plant material comprising fruits and berries selected from the group consisting of blueberries, blackberries, strawberries, cranberries, raspberries, red currants, black currants and cherries, without the addition of bisulfite ions, to produce a phenol-containing extract containing monomeric, oligomeric and polymeric phenolic compounds, including anthocyanins, proanthocyanidins and flavonoids present in the selected fruits or berries, and
- purifying said phenol-containing extract by removing non-phenolic compounds including sugars, cellulose, pectin, amino acids, proteins, nucleic acids, plant sterols, fatty acids, and triglycerides present in the selected fruits and berries, to obtain a composition having an enriched total phenol concentration of said anthocyanins, proanthocyanidins and flavonoids present in the selected fruits or berries greater than 12% and in vitro COX-2 inhibitory activity enhanced by a factor of at least 2.5 over a standard aspirin dose of 660 μg/mL.
A method of producing a composition enriched in total phenols prepared from plant material comprising the steps of:
- non-selectively extracting phenols from fruits and berries selected from the group consisting of blueberries and cranberries, without the addition of bisulfite ions, to produce a phenol-containing extract containing monomeric, oligomeric and polymeric phenolic compounds, including anthocyanins, proanthocyanidins and flavonoids present in the selected fruits or berries;
- and
- purifying said phenol-containing extract by removing non-phenolic compounds including sugars, cellulose, pectin, amino acids, proteins, nucleic acids, plant sterols, fatty acids, and triglycerides present in the selected fruits and berries, to obtain a-composition having an enriched total phenol concentration of said anthocyanins, proanthocyanidins and flavonoids present in the selected fruits or berries greater than 12% and exhibiting in vitro COX-2 inhibitory activity enhanced by a factor of at least 2.5 over a standard aspirin dose of 660 μg/mL.
A method of producing a composition enriched in total phenols prepared without the addition of bisulfite ions comprising the steps of:
- non-selectively extracting phenols from fruits and berries selected from the group consisting of blueberries, blackberries, strawberries, cranberries, raspberries, plums, red currants, black currants and cherries, without the addition of bisulfite ions, to produce a phenol-containing extract containing monomeric, oligomeric and polymeric phenolic compounds, including anthocyanins, proanthocyanidins and flavonoids present in the selected fruits or berries;
- and
- purifying said phenol-containing extract by removing non-phenolic compounds including sugars, cellulose, pectin, amino acids, proteins, nucleic acids, plant sterols, fatty acids, and triglycerides present in the selected fruits and berries, to obtain a composition having an enriched total phenol concentration of said anthocyanins, proanthocyanidins and flavonoids present in the selected fruits or berries greater than 12.5% and exhibiting in vitro antiviral activity against a virus which is more potent than an ED50 value of 100 μg/ML.
Dependencies are inferred from the claim text.