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US 7,682,626 B2Granted
Polyvinylethers for delivery of polynucleotides to mammalian cells
AssigneeRoche Madison Inc.
InventorsDavid B. Rozema, Darren Wakefield
Life of this patent
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Abstract
A class of polymers for delivery of polynucleotides to cells in described. More specifically, amphiphilic polyvinylethers and compositions containing amphiphilic polyvinylethers are described.
Claims15
A composition for delivery of a polynucleotide to a cell comprising:
- the polynucleotide and a cationic polyvinylether random copolymer, wherein the polyvinylether random copolymer comprises cationic monomeric units and alkyl or aryl monomeric units and is capable of lysing red blood cells.
A composition for delivery of a polynucleotide to a cell comprising:
- the polynucleotide, a cationic polymer, and an anionic reversibly modified polyvinylether random copolymer wherein the anionic reversibly modified polyvinylether random copolymer comprises hydrophobic monomeric units and 2-propionic-3-methylmaleic anhydride modified amine-containing monomeric units wherein:
- a) the modified polyvinylether random copolymer is not membrane active and
- b) cleavage of the 2-propionic-3-methylmaleic anhydride groups from the amine-containing monomeric units results in an unmodified polyvinylether random copolymer that is membrane active and capable of lysing red blood cells.
Dependencies are inferred from the claim text.