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US 7,682,623 B2Granted
Pharmaceutical composition for topical application
AssigneeFoamix Ltd.
InventorsMeir Eini, Dov Tamarkin
Life of this patent
Estimating the term…
Abstract
A pharmaceutical or cosmetic carrier or composition for topical application characterized by rheological properties which render the carrier or composition semi-solid at rest and a liquid upon application of shear forces thereto. The composition or carrier are prepared by mixing 1-25 percent of a solidifying agent and 75-99 percent of a hydrophobic solvent, by weight, wherein at least one of them has therapeutic or cosmetic benefits, in the presence or absence of a biologically active substance.
Claims51
A pharmaceutical composition comprising:
- (a) an oleaginous pharmaceutical carrier comprising, by weight:
- 75-99 percent of a hydrophobic solvent, and
- 1-10 percent of a solidifying agent, wherein said solidifying agent is not beeswax, is a solid at ambient temperature, and is selected from the group consisting of long chain fatty alcohols having at least 15 carbon atoms in its carbon backbone and fatty acids having at least 18 carbons in its carbon backbone;
- and
- (b) a therapeutically effective amount of a biologically active substance to treat a disease or disorder of the skin or mucosal membrane,
- wherein the pharmaceutical composition is semi-solid at rest and liquefies upon application of shear forces thereto.
3 more elements
A pharmaceutical composition comprising:
- (a) an oleaginous pharmaceutical carrier comprising, by weight:
- 75-99 percent of a hydrophobic solvent, wherein the hydrophobic solvent comprises an omega-3 or omega-6 oil, and
- 1-10 percent of a solidifying agent, wherein said solidifying agent is not beeswax, is a solid at ambient temperature, and is selected from the group consisting essentially of long chain fatty alcohols having at least 15 carbon atoms in its carbon backbone and fatty acids having at least 18 carbons in its carbon backbone;
- and
- (b) a therapeutically effective amount of a biologically active substance to treat a disease or disorder of the skin or mucosal membrane,
- wherein the pharmaceutical composition is semi-solid at rest and liquefies upon application of shear forces thereto.
3 more elements
A method of treating a disease or disorder of a skin or a mucosal membrane comprising:
- topically administering to the skin or the mucosal membrane a pharmaceutical composition containing, by weight, 1-10 percent of a solidifying agent, wherein the solidifying agent is not beeswax, is a solid at ambient temperature, and is selected from the group consisting of long chain fatty alcohols having at least 15 carbon atoms in its carbon backbone and fatty acids having at least 18 carbon atoms in its carbon backbone, and 75-99 percent of a hydrophobic solvent, wherein at least one of the solidifying agent and the hydrophobic agent has a therapeutic beneficial effect, and wherein the solidifying agent and the hydrophobic solvent are selected such that under ambient conditions, the composition is a semi-solid at rest and liquefies upon application of shear forces thereto,
- wherein the disease or disorder is selected from the group consisting of psoriasis, acne, seborrhea, seborrheic dermatitis, alopecia and excessive hair growth, ichthyosis, wounds, burns, cuts, ulcers, psoriasis, seborrheic dermatitis of the face and trunk, seborrheic blepharitis, contact dermatitis, stasis dermatitis and exfoliative dermatitis.
A method of treating a disease or disorder of a skin or a mucosal membrane comprising the step of topically administrating thereto a pharmaceutical composition containing:
- (a) a pharmaceutical carrier containing, by weight, 1-10 percent of a solidifying agent, wherein the solidifying agent is not beeswax, is a solid at ambient temperature, and is selected from the group consisting of long chain fatty alcohols having at least 15 carbon atoms in its carbon backbone and fatty acids having at least 18 carbon atoms in its carbon backbone, and 75-99 percent of a hydrophobic solvent;
- and
- (b) a therapeutically effective amount of a biologically active substance,
- wherein the pharmaceutical is semi-solid at rest and liquefies upon application of shear forces thereto, and
- wherein the biologically active substance is effective in the treatment of a disease or disorder selected from the group consisting of psoriasis, acne, seborrhea, seborrheic dermatitis, alopecia and excessive hair growth, ichthyosis, wounds, burns, cuts, ulcers, psoriasis, seborrheic dermatitis of the face and trunk, seborrheic blepharitis, contact dermatitis, stasis dermatitis and exfoliative dermatitis.
2 more elements
A method of treating dermatosis of a skin or a disorder of a mucosal membrane comprising the step of topically administering to the skin or the mucosal membrane a pharmaceutical composition containing,
- (a) a carrier comprising, by weight, 1-12 percent of a solidifying agent, wherein said solidifying agent is not beeswax, is a solid at ambient temperature, and is selected from the group consisting of long chain fatty alcohols having 18-22 carbons atoms in its carbon backbone and long chain fatty acids having 18-22 carbon atoms in its carbon backbone and 75-99 percent of a triglyceride hydrophobic solvent;
- and
- (b) a therapeutically effective amount of a biologically active substance that treats a symptom of a dermatosis,
- wherein the pharmaceutical composition is semi-solid at rest and liquefies upon application of shear forces thereto.
1 more element
A pharmaceutical composition comprising:
- (a) an oleaginous pharmaceutical carrier comprising, by weight, 75-99 percent of a liquid hydrophobic oil, and 1-10 percent of a solidifying agent that includes 12-hydroxy stearic acid, wherein the solidifying agent is not beeswax;
- and
- (b) a therapeutically effective amount of a biologically active substance to treat a disease or disorder of the skin or mucosal membrane,
- wherein the pharmaceutical composition is semi-solid at rest and liquefies upon application of shear forces thereto.
1 more element
A pharmaceutical composition comprising:
- (a) an oleaginous pharmaceutical carrier comprising, by weight:
- 75-99 percent of a liquid hydrophobic oil, and
- 1-10 percent of a solidifying agent, wherein the solidifying agent is not beeswax, is solid at ambient temperatures, and further wherein the solidifying agent is selected from the group consisting of long chain fatty alcohols having at least 15 carbon atoms in its carbon backbone and fatty acids having at least 18 carbons in its carbon backbone;
- and
- (b) a therapeutically effective amount of a biologically active substance to treat a disease or disorder of the skin or mucosal membrane,
- wherein the pharmaceutical composition is semi-solid at rest and liquefies upon application of shear forces thereto.
3 more elements
A method of treating a disease or disorder of a skin or a mucosal membrane comprising topically administering to the skin or the mucosal membrane a pharmaceutical composition containing:
- (a) an oleaginous pharmaceutical carrier comprising, by weight, 75-99 percent of a liquid hydrophobic oil, and 1-10 percent of a solidifying agent that includes 12-hydroxy stearic acid, and is not beeswax;
- and
- (b) a therapeutically effective amount of a biologically active substance to treat a disease or disorder of the skin or mucosal membrane selected from the group consisting of psoriasis, acne, seborrhea, seborrheic dermatitis, alopecia and excessive hair growth, ichthyosis, wounds, burns, cuts, ulcers, psoriasis, inflammation, seborrheic dermatitis of the face and trunk, seborrheic blepharitis, contact dermatitis, stasis dermatitis and exfoliative dermatitis,
- wherein the pharmaceutical composition is semi-solid at rest and liquefies upon application of shear forces thereto.
1 more element
Dependencies are inferred from the claim text.