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US 7,682,615 B2Granted
Immune modulating compounds from fungi
AssigneeBeKa Holding AS
InventorBjørn Kristiansen
Life of this patent
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Abstract
The present invention relates to compositions comprising polypeptides and polysaccharides. The compositions are in general immune modulating. The invention also discloses methods of producing these compositions using filamentous fungi cultivated in liquid medium. The compositions are useful for example in the treatment of immune compromised conditions.
Claims10
An isolated, aqueous liquid immune stimulating composition comprising a mixture of polysaccharides comprising the monosaccharide units galactose, mannose and glucose,
- wherein:
- the majority of the polysaccharides of the composition have a molecular weight of at least 1,000 Da wherein a first part of said polysaccharides have a molecular weight of less than 1,000,000 Da, wherein a second part of said polysaccharides have a molecular weight of at least 1,000,000 Da, wherein said mixture of polysaccharides comprises the monosaccharides galactose, mannose and glucose in the ratio 1:0.033 to 500:1 to 50, and wherein the composition is produced by a method comprising the steps of;
- a) cultivating a fungus of the genus Lentinus in a liquid growth medium under appropriate conditions to provide a suitable chemical and physical environment supporting the growth of a fungus of the genus Lentinus in the liquid growth medium,
- b) isolating the composition from said liquid growth medium by one or more size fractionation steps, and
- c) retaining said composition for further use.
2 more elements
Dependencies are inferred from the claim text.