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US 7,682,613 B2Granted
Anti-leukocyte recruitment therapy for the treatment of seizures and epilepsy
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsPaolo Francesco Fabene, Eugene C. Butcher, Gabriela Constantin
Life of this patent
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Abstract
Methods are provided for the prevention and treatment of seizures and epilepsy. It is shown herein that leukocyte recruitment plays a key role in the pathogenesis of epilepsy. Treatment with an agent that inhibits leukocyte recruitment has therapeutic and preventative effects in blocking recurrent seizures and epilepsy.
Claims1
A method of preventing seizures in an individual mammal that has epilepsy, said method comprising:
- administering to said individual mammal an effective amount of an antibody specific for an α4 integrin to inhibit the recurrence of seizures.
Dependencies are inferred from the claim text.