Powdered CBC system with improved reaction feature
AssigneeDoxa AB
InventorsLeif Hermansson, Håkan Engqvist
Life of this patent
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Abstract
The present invention deals with the initial hydration reaction of highly alkaline chemically bonded ceramic systems such as Ca-aluminate and Ca-silicate, exhibiting a controlled pH development, reduced from very high levels to be in a pH range of 7-9 by the use of an internal buffer system added to the CBC type biomaterial used. The invention is especially intended for endodontic, orthopaedic applications and/or soft tissue applications and/or drug delivery carrier applications.
Claims11
A powdered composition forming a chemically bonded ceramic biomaterial on hydration thereof, comprising (a) an alkaline component comprised of a material selected from the group consisting of calcium-aluminates, calcium-silicates and combinations thereof and forming a chemically bonded ceramic material, an initial pH of ≧10, on hydration thereof, and further comprising (b) a solid buffering salt of a mono-, di-, tri- or tetravalent mineral acid in an amount of 3-30% by volume further comprising an ingredient selected from the group consisting of pH sensitive drugs and/or bone growth promoting agents, prophylactically and/or diagnostically active agents to be released subsequently by the chemically bound ceramic biomaterial in vivo, therapeutic agents for pain relief, anesthetics, anti-infective agents and anti-inflammatory drugs, drugs for treatment of immunological disorders, hormonal disruption, clotting behavior, cancer, and combinations thereof.
A powdered composition forming a chemically bonded ceramic biomaterial on hydration thereof, comprising (a) an alkaline component comprised of a material selected from the group consisting of calcium-aluminates, calcium-silicates and combinations thereof and forming a chemically bonded ceramic material, an initial pH of ≧10, on hydration thereof, and further comprising (b) a solid buffering salt of a mono-, di-, tri- or tetravalent mineral acid in an amount of 3-30% by volume wherein the buffering salt (b) is impregnated in porous granules of component (a) and/or in an additional porous inert phase.
A composition forming a chemically bonded ceramic biomaterial on hydration thereof, comprising (a) an alkaline component forming a chemically bonded ceramic material, an initial pH of ≧10 on hydration thereof comprised of a material selected from the group consisting of calcium-aluminates, calcium-silicates and combinations thereof and (c) hydration liquid, and further comprising (b) a buffering salt of a mono-, di-, tri- or tetravalent mineral acid in an amount of 3-30% by volume based on the total volume of the constituents in dry state, or 5-20% by weight of the hydrating system, said composition further comprising an ingredient selected from the group consisting of pH sensitive drugs and/or bone growth promoting agents, prophylactically and/or diagnostically active agents to be released subsequently by the chemically bound ceramic biomaterial in vivo, therapeutic agents for pain relief, anesthetics, anti-infective agents and anti-inflammatory drugs, drugs for treatment of immunological disorders, hormonal disruption, clotting behavior, cancer, and combinations thereof.
Dependencies are inferred from the claim text.