Method and related system for measuring intracranial pressure

A system of using an ultrasound contrast agent to measure intracranial pressure in a target area filled with micro-bubbles formed by the injected contrast agent, the system comprising:

• a transmitter module for emitting an ultrasound signal having a bandwidth to the target area;
• a receiver module for receiving an echoed signal from a micro-bubble;
• and
• a signal processing module connected to the receiver module, the signal processing module comprising:
• a low-frequency capture unit for performing a spectral analysis on the echoed signal and extracting a low-frequency response, the low-frequency response formed by exciting a difference between two frequencies of a dual-frequency acoustic signal when the micro-bubbles are excited by the dual-frequency acoustic signal with the two frequencies, the difference being close to a DC component of a frequency spectrum, and the bandwidth of the low-frequency response being similar to the bandwidth of the ultrasound signal;
• a resonant frequency calculation unit for calculating a resonant frequency of the micro-bubble according to the low-frequency response;
• and
• a pressure calculation unit for calculating a size of the micro-bubble according to the resonant frequency and a property of the contrast agent, and further calculating an intracranial pressure of the target area.