US 7,680,244 B2Granted

Ocular radiosurgery

AssigneeOraya Therapeutics, Inc.

InventorsMichael Gertner, Erik Chell, Steven D. Hansen, Mark Arnoldussen, Matt Herron, Kuang-Hung Pan

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Abstract

A radiosurgery system is described that delivers a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, ocular structures are placed in a global coordinate system, based on ocular imaging, which leads to direction of an automated positioning system. In some embodiments, the position of an ocular structure is tracked and related to a radiosurgery system. In some embodiments, a treatment plan is utilized for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial aids in positioning the system. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.

Claims29

Dependent claims

A method, of planning radiation therapy for an eye, comprising:

preparing a treatment plan for delivery of radiation to a target at a region of the eye, the preparing comprising:
determining a first dose of radiation to be delivered from a radiation source outside the eye to the target;
determining at least one of a width of at least one x-ray radiation beam and a distance from the radiation source to the target, and
determining a trajectory of the x-ray beam;
and
wherein the at least one of the width of the at least one x-ray radiation beam, the distance from the radiation source to the target, and the trajectory of the beam is selected such that an amount of radiation to be received outside the target from the radiation source is equal to or less than about 40 percent of the first dose;
wherein determining the trajectory of the beam is based on at least a point on the retina and a point on an outer surface of the eye, and
outputting information, to an output module, indicative of at least one of the width of the at least one x-ray radiation beam, the distance from the radiation source to the target, and the trajectory of the beam;
and
wherein the x-ray beam has a maximum energy of less than about 400 keV.

7 more elements

Dependencies are inferred from the claim text.

Facts

Application: 11/873,386Filed 16 Oct 2007 · us provisional application
Priority: 16 Oct 2006
Published: US 2008/0187098 A17 Aug 2008
Granted: 16 Mar 2010
Term ends: Not estimatedThe source records don’t support an estimate.

Classification12 codes

A61N 5/1049
Monitoring, verifying, controlling systems and methods: for verifying the position of the patient with respect to the radiation beam
A61B 6/506
Specially adapted for specific body parts; specially adapted for specific clinical applications: for diagnosis of nerves
A61F 9/009
Using laser: auxiliary devices making contact with the eyeball and coupling in laser light, e.g. goniolenses
A61N 5/1017
Intracavitary radiation therapy: treatment of the eye, e.g. for "macular degeneration"

Family

Application60/829,676Us provisional application · filed 16 Oct 2006
Application60/862,044Us provisional application · filed 18 Oct 2006
Application60/862,210Us provisional application · filed 19 Oct 2006
Application60/869,872Us provisional application · filed 13 Dec 2006
Application60/922,741Us provisional application · filed 9 Apr 2007
Application60/933,220Us provisional application · filed 4 Jun 2007
US 2008/0187098 A1Pre-grant publication · published 7 Aug 2008
US 7,680,244 B2This patent

From the US filing history. Foreign family members aren’t listed.