Process for preparation of diphosphine compounds and intermediates for the process
AssigneeTakeda Pharmaceutical Company Limited
InventorsMitsutaka Goto, Mitsuhisa Yamano
Life of this patent
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Abstract
A production method of a compound represented by the formula wherein R1a, R1b, R1c, R1d, R1e, R1f, R2a, R2b, R2c, R2d, R2e and R2f are the same or different and each is a hydrogen atom and the like, and R3, R4, R5, R6, R7, R8, R9 and R10 are the same or different and each is a hydrogen atom and the like, or a salt thereof, which comprises reacting a compound represented by the formula wherein X is a leaving group and other symbols are as defined above, or a salt thereof, with a phosphine-borane complex represented by the formula wherein the symbols are as defined above, or a salt thereof, in a solvent in the presence of an amine and a nickel catalyst, is provided.
Claims6
A phosphine-borane complex represented by the formula
- wherein R3′, R5′, R6′ and R8′ are each a lower alkyl group, and R4′ and R7′ are each a hydrogen atom, or a salt thereof.
A phosphine-borane complex represented by the formula
- wherein R3′, R5′, R6′ and R8′ are each a lower alkyl group, and R4′ and R7′ are each a lower alkoxy group, or a salt thereof.
A phosphine-borane complex represented by the formula
- wherein R5′ and R6′ are each a hydrogen atom, and R3′ and R4′, and R7′ and R8′ each form a methylenedioxy group, or a salt thereof.
A method of producing a phosphine-borane complex represented by the formula
- wherein R3′, R5′, R6′ and R8′ are each a lower alkyl group, and R4′ and R7′ are each a hydrogen atom, or a salt thereof,
- said method comprising reducing a compound represented by the formula
- wherein R3′, R4′, R5′, R6′, R7′ and R8′ are as defined above, or a salt thereof, with lithium aluminum hydride in the presence of cerium chloride and sodium borohydride.
A method of producing a phosphine-borane complex represented by the formula
- wherein R3′, R5′, R6′ and R8′ are each a lower alkyl group, and R4′ and R7′ are each a lower alkoxy group, or a salt thereof,
- said method comprising reducing a compound represented by the formula
- wherein R3′, R4′, R5′, R6′, R7′ and R8′ are as defined above, or a salt thereof, with lithium aluminum hydride in the presence of cerium chloride and sodium borohydride.
A method of producing a phosphine-borane complex represented by the formula
- wherein R5′ and R6′ are each a hydrogen atom, and R3′ and R4′, and R7′ and R8′ each form a methylenedioxy group, or a salt thereof,
- said method comprising reducing a compound represented by the formula
- wherein R3′, R4′, R5′, R6′, R7′ and R8′ are as defined above, or a salt thereof, with lithium aluminum hydride in the presence of cerium chloride and sodium borohydride.
Dependencies are inferred from the claim text.