US 7,678,927 B2 · Process for lactonization in the preparation of statins

Abstract

The present invention relates to an improved and industrial friendly process for lactonization to produce compound of the Formula [I], from compound of the Formula [II] in presence of an inorganic compound as a suitable lactonizing agent, preferably alkali metal hydrogen sulfate, and crystallizing the obtained lactone product in a solvent; or treating compound of the Formula [II] in the presence of an inorganic compound preferably alkali metal hydrogen sulfate using phase transfer catalyst in heterogeneous phase followed by crystallizing the obtained lactone product in a solvent.

Claims12

Dependent claims

An improved lactonization process in the preparation of compound of Formula [I], the process comprising treating the compound of Formula [II] with an alkali metal hydrogen sulfate used as a lactonizing agent in the presence of a phase transfer catalyst,

wherein R is a hydrogen atom or a methyl group, R1 is a hydrogen atom or a lithium, sodium, potassium, or an ammonium cation and R2 is a hydrogen atom or a methyl group or a hydroxyl group.

Dependencies are inferred from the claim text.

Process for lactonization in the preparation of statins

Life of this patent

Process for lactonization in the preparation of statins

Life of this patent

Abstract

Claims12