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US 7,678,918 B2Granted
Intermediates for imidazonaphthyridines
Assignees3M Innovative Properties Company, Graceway Pharmaceuticals, LLC
InventorsJohn F. Gerster, Kyle J. Lindstrom, Stephen L. Crooks, Philip D. Heppner, Gregory J. Marszalek, Peter V. Maye, Bryon A. Merrill, John W. Mickelson, Michael J. Rice
Life of this patent
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Abstract
Imidazonaphthyridine and tetrahydroimidazonaphthyridine compounds induce the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compounds exhibit antiviral and antitumor properties. Methods of preparing the compounds and intermediates useful in the preparation of the compounds are disclosed.
Claims1
A compound of formula
- wherein
- A is ═N—CR═CR—CR═;
- ═CR—N═CR—CR═;
- ═CR—CR═N—CR═;
- or ═CR—CR═CR—N═;
- each R is independently selected from the group consisting of hydrogen, C1-10 alkyl, C1-10 alkoxy, halogen and trifluoromethyl;
- and
- R9 is H or C1-10 alkyl.
5 more elements
Dependencies are inferred from the claim text.